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首页> 外文期刊>American Journal of Ophthalmology: The International Journal of Ophthalmology >Smoking as a risk factor for cystoid macular edema complicating intermediate uveitis.
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Smoking as a risk factor for cystoid macular edema complicating intermediate uveitis.

机译：吸烟是黄斑囊样水肿并发中级葡萄膜炎的危险因素。

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摘要

PURPOSE: To describe risk factors for the presence of cystoid macular edema (CME) among patients presenting with intermediate uveitis. DESIGN: Cross-sectional study. METHODS: SETTINGS: Single-center, academic practice. STUDY POPULATION: Two hundred and eight patients with intermediate uveitis evaluated from July 1, 1984 through September 30, 2006. PROCEDURES: Clinical and demographic data were entered retrospectively into a database and analyzed. OUTCOME MEASURES: Presence of CME at presentation to our clinic; risk factors for presenting with CME. RESULTS: Of the 208 patients, 74% had bilateral intermediate uveitis, yielding 363 affected eyes. Eighty-nine patients (43%) had CME in at least one eye at the time of presentation to our clinic. After controlling for potentially confounding variables including demographics, duration of disease, active intraocular inflammation, history of diabetes mellitus or hypertension, and presence of epiretinal membrane, actively smoking at presentation was associated with a four-fold increased risk of CME at presentation vs never smoking (odds ratio (OR), 3.90; 95% confidence interval (CI), 1.43, 10.66; P = .008). Former smoking also appeared to increase the risk of CME at presentation in the multivariate analysis, but the result was of borderline statistical significance (OR, 1.97; 95% CI, 0.99, 3.94; P = .055). After adjusting for confounding, there was a 4% increased risk of CME at presentation for each cigarette smoked per day (OR, 1.04; 95% CI, 1.01, 1.7; P = .005). CONCLUSIONS: CME was a common structural ocular complication observed in our cohort. Current smoking was associated with a dose-dependent increased risk of having CME at the time of presentation to our clinic.
机译：目的：描述中度葡萄膜炎患者中存在黄斑囊样水肿（CME）的危险因素。设计：横断面研究。方法：设置：单中心的学术实践。研究人群：1984年7月1日至2006年9月30日对208例中度葡萄膜炎患者进行了评估。程序：将临床和人口统计学资料回顾性输入数据库并进行分析。观察指标：在我们诊所就诊时存在CME;出现CME的危险因素。结果：在208例患者中，有74％患有双侧中间葡萄膜炎，产生363只患眼。在向我们的诊所就诊时，有八十​​九名患者（43％）的至少一只眼睛患有CME。在控制了可能令人困惑的变量后，包括人口统计学，疾病持续时间，活动性眼内炎症，糖尿病或高血压病史以及存在视网膜前膜的存在，就诊时积极吸烟与就诊时CME风险比不吸烟增加了四倍（赔率（OR），3.90; 95％置信区间（CI），1.43，10.66; P = 0.008）。在多变量分析中，前吸烟似乎也增加了CME的风险，但结果具有统计学意义（OR，1.97; 95％CI，0.99，3.94; P = .055）。调整混杂因素后，每天抽烟的每支卷烟出现CME的风险增加4％（OR，1.04; 95％CI，1.01，1.7; P = .005）。结论：CME是在我们队列中观察到的一种常见的结构性眼部并发症。目前的吸烟与在我们诊所就诊时CME的剂量依赖性风险增加相关。

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