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首页> 外文期刊>Biotechnology Letters >Gene therapy for diabetic rats by electroporational transfer of naked plasmid with human pre-pro-insulin gene into skeletal muscle
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Gene therapy for diabetic rats by electroporational transfer of naked plasmid with human pre-pro-insulin gene into skeletal muscle

机译：通过将人胰岛素原胰岛素原裸质粒电穿孔转移到骨骼肌中，对糖尿病大鼠进行基因治疗

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摘要

A naked plasmid with human pre-pro-insulin gene was transferred into skeltal muscale of diabetic rats by electric pulses and gene expression was detected. Blood glucose concentration was decreased from 24 mmol l~(-1) to 8.5 mmol l~(-1). Circulating insulin-like protein was increased significantly to 15-20 #mu#U ml~(-1), while that of the control group injected with the empty vector remained at less than 10 #mu#U ml~(-1). The low blood glucose concentration lasted for more than two months. These studies indicate that electroporational transfer of plasmid with human pre-pro-insulin gene into skeletal muscle could be a potential method of gene therapy for human diabetes mellitus.
机译：用电脉冲将裸露的具有人胰岛素原前体基因的质粒转移到糖尿病大鼠的骨骼肌鳞中，检测基因表达。血糖浓度从24 mmol l〜（-1）降至8.5 mmol l〜（-1）。循环胰岛素样蛋白显着增加至15-20＃mu＃U ml〜（-1），而注射空载体的对照组的循环胰岛素样蛋白仍低于10＃mu＃U ml〜（-1）。低血糖浓度持续了两个多月。这些研究表明，具有人胰岛素原前体基因的质粒的电穿孔转移可能是人糖尿病基因治疗的一种潜在方法。

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