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首页> 外文期刊>Amino acids >Translational and post-translational modifications of proteins as a new mechanism of action of Alpha-Interferon:Review article
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Translational and post-translational modifications of proteins as a new mechanism of action of Alpha-Interferon:Review article

机译：蛋白质的翻译和翻译后修饰是α-干扰素的新作用机理：综述文章

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Interferon-alpha(IFNalpha)is a recombinant protein widely used in the therapy of several neoplasms such as myeloma,renal cell carcinoma,epidermoid cervical and head and neck tumours and melanoma.IFNa,the first cytokine to be produced by recombinant DNA technology,has emerged as an important regulator of cancer cell growth and differentiation,affecting cellular communication and signal transduction pathways.However,the way by which tumour cell growth is directly suppressed by IFNa is not well known.Wide evidence exists on the possibility that cancer cells undergo apoptosis after the exposure to the cytokine.Here we will discuss data obtained by us and others on the post-translational regulation of the expression of proteins involved in the occurrence of apoptotic process such as tissue transglutaminase(tTG)or in the modulation of cell cycle such as the cyclin-dependent kinase inhibitor p27.This new way of regulation of p27 and tTG occurs through the modulation of their proteasome-dependent degradation induced by the cytokine.We will also review the involvement of protein synthesis machinery in the induction of cell growth inhibition by IFNa.In details,we will describe the effects of IFNa on the expression and activity of the protein kinase dependent from dsRNA(PKR)and on the eukaryotic initiation factor of protein synthesis 5A(eIF-5A)and their correlations with the regulation of cancer cell growth.These data strongly suggest that the antitumour activity of IFNa against human tumours could involve still unexplored mechanisms based on post-translational and translational control of the expression of proteins that regulate cell proliferation and apoptosis.
机译：干扰素-α（IFNα）是一种重组蛋白，广泛用于治疗多种肿瘤，例如骨髓瘤，肾细胞癌，表皮样宫颈癌和头颈部肿瘤以及黑素瘤。IFNa是第一个通过重组DNA技术生产的细胞因子。作为癌细胞生长和分化的重要调节剂，它影响细胞的通讯和信号转导通路。然而，IFNa直接抑制肿瘤细胞生长的方法尚不清楚。广泛的证据表明癌细胞发生凋亡的可能性在这里，我们将讨论由我们和其他人获得的有关翻译后调控凋亡过程中发生的蛋白质表达的数据，例如组织转谷氨酰胺酶（tTG）或细胞周期调控等。作为细胞周期蛋白依赖性激酶抑制剂p27。这种调节p27和tTG的新方法是通过调节其蛋白酶体依赖性我们还将审查蛋白质合成机制在IFNa诱导的细胞生长抑制中的作用。详细地，我们将描述IFNa对dsRNA依赖的蛋白激酶的表达和活性的影响。 PKR）以及蛋白合成5A（eIF-5A）的真核起始因子及其与癌细胞生长调控的相关性。这些数据强烈表明IFNa对人肿瘤的抗肿瘤活性可能还涉及基于后激活的机制。调节细胞增殖和凋亡的蛋白质表达的翻译和翻译控制。

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