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首页> 外文期刊>Amino acids >Characteristics of basal taurine release in the rat striatum measured by microdialysis
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Characteristics of basal taurine release in the rat striatum measured by microdialysis

机译：微透析法测定大鼠纹状体基底牛磺酸的释放特征

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Taurine is a sulfur-containing amino acid thought to be an osmoregulator,neurotransmitter or neuromodulator in the brain.Our objective was to establish how much taurine is released in the striatum and examine the mechanisms controlling extracellular taurine concentrations under resting conditions.The experiments were made on rats by microdialysis in vivo.Changes in taurine were compared with those in glutamate,glycine and the non-neuroactive amino acid threonine.Using the zero net flux approach we showed the extracellular concentration of taurine to be 25.2 ± 5.1 muM.Glutamate was increased by tetrodotoxin and decreased by Ca~(2+) omission,glycine and threonine were not affected and both treatments increased extracellular taurine.The basal taurine release was increased by the taurine transport inhibitor guanidinoethanesulfonate and reduced by the anion channel blocker 4-acetamido-4'-isothiocyana-tostilbene-2,2'-disulfonic acid.
机译：牛磺酸是一种含硫氨基酸，被认为是大脑中的渗透调节剂，神经递质或神经调节剂。我们的目标是确定纹状体中释放出多少牛磺酸，并研究在静息条件下控制细胞外牛磺酸浓度的机制。体内牛磺酸的变化与牛磺酸，谷氨酸，甘氨酸和非神经活性氨基酸苏氨酸的变化进行了比较。使用零净通量方法，我们显示牛磺酸的细胞外浓度为25.2±5.1μM。通过河豚毒素的释放和Ca〜（2+）的减少而降低，甘氨酸和苏氨酸不受影响，并且两种处理均增加了细胞外牛磺酸。牛磺酸转运抑制剂胍基乙烷磺酸盐增加了基础牛磺酸的释放，而阴离子通道阻断剂4-acetamido-4则降低了基础牛磺酸的释放。 '-异硫氰酸-tostilbene-2,2'-二磺酸。

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