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Immune status of patients with different outcomes of acute hepatitis C

机译：急性丙型肝炎不同结果的患者免疫状态

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AIM: To ascertain parameters of immune response significant for prognosis of the disease outcome in patients with acute hepatitis C (AHC). MATERIAL AND METHODS: Seventy two examinees were divided into three groups: 30 patients of group 1 had AHC; 29 patients of group 2 had chronic hepatitis C (CHC) with the disease history 3-10 years; 13 AHC convalescents who had the disease 3-10 years ago. The control group consisted of 10 healthy subjects. The following parameters of immune status were studied: CD3+, CD4+, CD8+, CD16+, CD20+, HLA-DR+CD3+, CD95+, O-lymphocytes. RESULTS: By clinicobiochemical picture and the results of 12-month follow-up RT-PCR investigations of blood HCV RNA, AHC patients were divided into two groups: in 18 (72%) of 25 patients AHC became chronic, 7 (28%) patients achieved convalescence. The proportion and absolute number of subpopulations of lymphocytes CD8+, CD20+, CD16+ as well as CD4/CD8 in patients with AHC with different outcomes did not differ from the controls. AHC convalescents and patients with AHC transformation into chronic hepatitis had in the acute period of the disease much higher absolute number of subpopulations of the lymphocytes CD3+, CD4+, HLA-DR+CD3+ vs the controls. In patients with chronic hepatitis C with elevated levels of AlAT, 3-10 year follow-up registered significantly higher absolute amount of CD8+, CD3+, CD4+, HLA-DR+CD3+ vs the controls. Only patients with AHC which later became chronic had for 6 months of the disease significantly elevated absolute number of O-lymphocytes vs the controls. CONCLUSION: A high absolute count of O-lymphocytes in AHC patients may indicate probable development of chronic hepatitis C.
机译：目的：确定急性丙型肝炎（AHC）患者疾病结果预后的免疫反应参数。材料和方法：72例考生分为三组：30名患者1患者患有AHC; 29款组患者患有慢性丙型肝炎（CHC），疾病病史3-10岁; 13 AHC伴随着3-10年前疾病的康全人士。对照组由10个健康的科目组成。研究了免疫状态的以下参数：CD3 +，CD4 +，CD8 +，CD16 +，CD20 +，HLA-DR + CD3 +，CD95 +，O淋巴细胞。结果：通过临床血液化学图片和12个月的血液HCV RNA调查的结果，AHC患者分为两组：18例（72％）25例AHC变成慢性，7名（28％）患者恢复期。淋巴细胞CD8 +，CD20 +，CD16 +的比例和绝对数量和AHC患者与不同结果的患者CD4 / CD8的比例与对照不同。 AHC调控器和AHC转化患者转化为慢性肝炎的急性期在疾病的急性时期，淋巴细胞CD3 +，CD4 +，HLA-DR + CD3 +与对照的急性次数。在慢性丙型肝炎患者患者中升高的Alat升高，3-10年后续后续注册明显较高的CD8 +，CD3 +，CD4 +，HLA-DR + CD3 + VS对照。只有AHC的患者才有6个月的疾病，患者的6个月显着升高了O-淋巴细胞的绝对数量vs对照。结论：AHC患者O淋巴细胞的高度绝对计数可能表明慢性丙型肝炎的可能发育。

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