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Cytomegalovirus infection of the gastrointestinal tract in patients with HIV-infection

机译：艾滋病毒感染患者胃肠道患者的巨细胞病毒感染

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AIM: To study clinical and morphological characteristics of gastrointestinal cytomegalovirus (CMV) infection in HIV-infected subjects. MATERIAL AND METHODS: The examination of 70 HIV-infected subjects (all of them had secondary diseases, AIDS, CMV infection in the gastrointestinal tract; mean age 31.2 +/- 1.4 years) observed from 1993-2005 included conduction of flow cytofluorimetry (to assess immunity), esophagogastroduodenoscopy, colonoscopy, PCR (to assay CMV DNA in blood leukocytes), examination of biopsy and autopsy samples for CMV DNA and other pathogens of opportunistic diseases). There were 55 lethal outcomes. In autopsy, a total macroscopic and microscopic examination of the gastrointestinal tract was made. Serial histotopographic sections were studied with a wide spectrum of histological stains. RESULTS: CMV gastrointestinal lesion was diagnosed in 38.9% of 180 HIV-infected subjects who had stomatitis, pharyngitis, esophagitis, gastritis, enteritis, enterocolitis or colitis. Diagnostic criteria of viral lesion were high blood concentrations of CMV DNA, the presence of cytomegalocells, CMV DNA in biopsy or autopsy material. CONCLUSION: CMV infection manifested with severe pain, loss of weight, weakness, remitting fever. Gastrointestinal lesions were erosive-ulcerous or ulceronecrotic. The following pathogenetic chain of CMV infection course in the gastrointestinal tract was established: vasculitis--microcirculatory disorders--segmental ischemia--necrosis with inflammatory infiltration and CMV transformation of the cells--fibrosing--cicatricial transformation of the organ wall. Developing sclerosis due to CMV involvement of the intestine may promote cancer, but this should be proved in further studies. CMV gastrointestinal infection was successfully treated by cimeven (ganciclovir) and valcit (valganciclovir). The effect was achieved in 91% cases.
机译：目的：研究艾滋病毒感染受试者胃肠道胞嘧啶病毒（CMV）感染的临床和形态学特征。材料和方法：检查70个艾滋病毒感染的受试者（所有这些受试者（所有这些受试者都有次要疾病，艾滋病，CMV感染在胃肠道中;平均年龄31.2 + -1-4岁）从1993 - 2005年观察到流动细胞流荧光的传导（至评估免疫），食管胃透明度，结肠镜检查，PCR（在血白细胞中测定CMV DNA），对CMV DNA和机会疾病的其他病原体检查活检和尸检样品）。有55个致命的结果。在尸检中，制备了胃肠道的总宏观和微观检查。通过宽的组织学污渍研究了连续组分分析部分。结果：CMV胃肠病变诊断为180名艾滋病毒感染受试者的38.9％，受口腔炎，咽炎，食管炎，胃炎，肠炎，内肠炎或结肠炎。病毒病变的诊断标准是CMV DNA的高血液浓度，在活组织检查或尸检材料中存在缩细胞，CMV DNA。结论：CMV感染表现出严重的疼痛，重量丧失，弱点，饲养发烧。胃肠病变是糜烂性溃疡或溃疡性的。建立了以下胃肠道CMV感染课程的以下致病链：血管炎 - 微循环障碍 - 节段缺血 - 炎症渗透和细胞CCIBRACING - 器官壁的CicaTricial转换的血压转化。由于CMV的肠道涉及肠道可能促进癌症的发展，但这应该在进一步的研究中证明这一点。 CMV胃肠感染被Cimeven（Ganciclovir）和Valcit（Valganciclovir）成功处理。该效果在91％的情况下实现。

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