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首页> 外文期刊>Birth defects research, Part A. Clinical and molecular teratology >Quality and content of abstracts in papers reporting about drug exposures during pregnancy.
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Quality and content of abstracts in papers reporting about drug exposures during pregnancy.

机译：报告怀孕期间药物暴露的论文摘要的质量和内容。

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BACKGROUND: Most clinicians read only the abstract of papers in scientific journals. Therefore, it is very important that abstracts contain as much information as possible, to summarize the data succinctly. Our objectives were to evaluate the quality of information in abstracts reporting human fetal outcomes following drug exposure during pregnancy. METHODS: We developed quality criteria based on previous work, modifying them for use with pregnancy outcomes. Quality scores were calculated as present/absent for all of the equally weighted criteria, then expressed as percentages (present/[present + absent]). We examined a random sample of 100 abstracts obtained through searches of MEDLINE, EMBASE, and the Web of Science databases from 1990 to 2005. Average quality scores were compared across designs (cohort, case-control, meta-analysis, and mixed design) Using Kruskal-Wallis ANOVA and structured/unstructured formats using Student's t test. RESULTS: The overall average quality was 59.2% +/- 14% (median, 61.5%; range, 15.4-83.3%). Quality was not significantly different across designs (P = .16) or between structured and unstructured abstracts (P = .44). Quality scores increased over time (Rho = 0.23, P = .02). Most frequently absent were baseline risk (94%), drug dose (91%), nonsignificant P values (72%), confounders (69%), significant P values (57%), and risk difference (48%). CONCLUSIONS: Abstracts provide insufficient information, particularly baseline risk values, for readers to make evidence-based decisions regarding drug use during pregnancy. Efforts need to be made to improve the quality of abstracts and include critical information such as baseline risk.
机译：背景：大多数临床医生仅在科学期刊上阅读论文摘要。因此，摘要包含尽可能多的信息以简洁地汇总数据非常重要。我们的目标是评估在怀孕期间接触药物后人类胎儿结局的摘要中信息的质量。方法：我们根据先前的工作制定了质量标准，并对其进行了修改以用于妊娠结局。对于所有相等加权的标准，将质量得分计算为存在/不存在，然后表示为百分比（存在/ [存在+缺失]）。我们检查了1990年至2005年通过搜索MEDLINE，EMBASE和Web of Science数据库获得的100个摘要的随机样本。比较了各个设计（群组，病例对照，荟萃分析和混合设计）的平均质量得分，使用学生t检验的Kruskal-Wallis方差分析和结构化/非结构化格式。结果：总体平均质量为59.2％+/- 14％（中位数为61.5％;范围为15.4-83.3％）。跨设计（P = .16）或结构化和非结构化抽象之间的质量没有显着差异（P = .44）。质量得分随时间增加（Rho = 0.23，P = .02）。最不常见的是基线风险（94％），药物剂量（91％），非显着P值（72％），混杂因素（69％），显着P值（57％）和风险差异（48％）。结论：摘要提供的信息不足，尤其是基线风险值，无法使读者做出有关怀孕期间药物使用的循证决策。需要努力提高摘要的质量，并包括关键信息，例如基线风险。

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