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首页> 外文期刊>American Journal of Orthodontics and Dentofacial Orthopedics >Stabilization of tooth movement by administration of reveromycin A to osteoprotegerin-deficient knockout mice
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Stabilization of tooth movement by administration of reveromycin A to osteoprotegerin-deficient knockout mice

机译：通过对骨保护素缺乏的基因敲除小鼠施用雷维霉素A来稳定牙齿运动

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Introduction: In this study, mechanical stress in the form of tooth movement was applied to osteoprotegerindeficient knockout mice, which served as an animal model for juvenile Paget's disease. To compare and evaluate bone turnover and response of the surrounding bony tissue, we administered reveromycin A. We also investigated the ability of reveromycin A to control osteoclastic activity in juvenile Paget's disease. Methods: Eight-week-old male osteoprotegerin-deficient knockout and wild-type mice were injected with reveromycin A (15 mg/kg of body weight) intraperitoneally twice daily. An elastic module was inserted interproximally between the maxillary left first and second molars. Results: Administration of reveromycin A to osteoprotegerin- deficient knockout mice reduced tooth movement distances, increased bone volumes at the interradicular septum, decreased osteoclast counts, and reduced serum alkaline phosphatase and tartrate resistant acid phosphatase. Reveromycin A administration also caused a temporal shift in peak Runx2 staining in osteoprotegerin-deficient knockout mice so that the overall staining time course was similar to that observed for wild-type mice. Conclusions: Reveromycin A administration in osteoprotegerin-deficient knockout mice inhibited bone resorption and normalized bone formation. As a result, normal bone turnover was obtained.
机译：简介：在这项研究中，以牙齿运动形式的机械应力被应用于缺乏骨保护素的基因敲除小鼠，该小鼠充当了少年Paget病的动物模型。为了比较和评估骨转换和周围骨组织的反应，我们使用了雷维霉素A。我们还研究了雷维霉素A控制少年Paget病中破骨细胞活性的能力。方法：每天两次向八周大的雄性骨保护素缺陷型基因敲除和野生型小鼠腹膜内注射白霉素A（15 mg / kg体重）。在上颌左第一磨牙和第二磨牙之间插入弹性模块。结果：对缺乏骨保护素的基因敲除小鼠给予白霉素A可以减少牙齿移动距离，增加小梁间隔处的骨量，减少破骨细胞计数，并降低血清碱性磷酸酶和抗酒石酸酸性磷酸酶。 Reveromycin A的给药还导致骨保护蛋白缺陷型基因敲除小鼠的Runx2染色峰值出现时间变化，因此总染色时间与野生型小鼠相似。结论：在骨保护素缺陷型基因敲除小鼠中施用利福霉素A可以抑制骨吸收和使骨形成正常化。结果，获得了正常的骨转换。

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