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首页> 外文期刊>American journal of otolaryngology >Atypical culture-negative skull base osteomyelitis masquerading as advanced nasopharyngeal carcinoma
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Atypical culture-negative skull base osteomyelitis masquerading as advanced nasopharyngeal carcinoma

机译：非典型培养阴性的颅底骨髓炎伪装成晚期鼻咽癌

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摘要

Skull base osteomyelitis typically arises as a complication of otogenic or sinonasal infections in immunocompromised patients. A much rarer entity, atypical skull base osteomyelitis is not associated with an obvious infective source. Atypical and culture-negative skull base osteomyelitis is even rarer and hampers diagnosis, as its clinical presentation is remarkably similar to skull base neoplasms. We report a case of extensive skull base osteomyelitis with orbital apex syndrome and multiple lower cranial nerve palsies which initially masqueraded as possible advanced nasopharyngeal carcinoma. Extensive investigations and consult with an infectious diseases specialist aided in elucidation of the correct diagnosis. Through this article, we emphasize that skull base osteomyelitis must be considered in the setting of headache, cranial neuropathies, elevated inflammatory markers and abnormal imaging findings. Early tissue sampling for histology, stainings and cultures and prompt appropriate treatment may prevent or arrest further complications. (c) 2016 Elsevier Inc. All rights reserved.
机译：颅底型骨髓炎通常是免疫功能低下患者的耳源性感染或鼻窦感染的并发症。非典型颅底骨髓炎是一种罕见得多的实体，与明显的感染源无关。非典型和培养阴性的颅底骨髓炎更罕见，而且诊断也很困难，因为其临床表现与颅底肿瘤非常相似。我们报告一例广泛的颅底骨髓炎伴眶尖综合征和多发性下颅神经麻痹，最初被伪装成可能的晚期鼻咽癌。进行广泛的调查并咨询传染病专家，以阐明正确的诊断。通过这篇文章，我们强调在头痛，颅神经病变，炎症标记升高和影像学表现异常的情况下必须考虑颅底骨髓炎。早期组织取样进行组织学，染色和培养，并及时采取适当的治疗措施，可以预防或阻止进一步的并发症。 （c）2016 Elsevier Inc.保留所有权利。

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