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首页> 外文期刊>Amyloid: the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis >CSF levels of A beta 1-38/A beta 1-40/A beta 1-42 and C-11 PiB-PET studies in three clinical variants of primary progressive aphasia and Alzheimer's disease
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CSF levels of A beta 1-38/A beta 1-40/A beta 1-42 and C-11 PiB-PET studies in three clinical variants of primary progressive aphasia and Alzheimer's disease

机译：在原发性进行性失语症和阿尔茨海默氏病的三种临床变体中，A beta 1-38 / A beta 1-40 / A beta 1-42和C-11 PiB-PET研究的CSF水平

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Primary progressive aphasia (PPA) is a cognitive syndrome characterized by progressive and isolated language impairments due to neurodegenerative diseases. Recently, an international group of experts published a Consensus Classification of the three PPA clinical variants (naPPA, svPPA and lvPPA). We analyzed 24 patients with PPA by cognitive functions, neuroimaging (MRI, Tc-99m ECD-SPECT, C-11 PiB-PET and FDG-PET) and cerebrospinal fluid (CSF) analysis (ptau-181, A beta 1-42, A beta 1-40 and A beta 1-38), to elucidate relationships between neuroimaging studies and biochemical findings in the three PPA clinical variants. Cognitive and speech functions were measured by mini-mental state examination and standard language test of aphasia. The patients with lvPPA showed significant decreases in CSF A beta 1-42 and ratios of A beta 1-42/A beta 1-40 and A beta 1-42/A beta 1-38, and significant increases in CSF ptau-181 and ratios of ptau-181/A beta 1-42 and ptau-181/A beta 1-38; these findings were similar to those of patients with Alzheimer's disease (AD). We observed a higher frequency of the ApoE epsilon 4 allele in the lvPPA patients relative to the two other PPA variants. In C-11 PiB-PET of lvPPA patients, PiB positive findings were detected in cortices of frontal, temporal and parietal lobes and the posterior cingulate, where massive A beta may accumulate due to AD. Our results of AD-CSF markers including A beta 1-38 and C-11 PiB-PET in the lvPPA patients demonstrate a common pathological mechanism with the occurrence of AD.
机译：原发性进行性失语症（PPA）是一种认知综合征，其特征是由于神经退行性疾病而导致进行性和孤立性语言障碍。最近，一个国际专家小组发布了三种PPA临床变异（naPPA，svPPA和lvPPA）的共识分类。我们通过认知功能，神经影像学检查（MRI，Tc-99m ECD-SPECT，C-11 PiB-PET和FDG-PET）和脑脊液（CSF）分析（ptau-181，A beta 1-42， Beta 1-40和A beta 1-38），以阐明三种PPA临床变体中神经成像研究与生化发现之间的关系。认知和言语功能通过小精神状态检查和失语症标准语言测验来测量。 lvPPA患者显示出CSF A beta 1-42和A beta 1-42 / A beta 1-40和A beta 1-42 / A beta 1-38的比率显着降低，而CSF ptau-181和ptau-181 / A beta 1-42和ptau-181 / A beta 1-38的比率;这些发现与阿尔茨海默氏病（AD）患者的发现相似。相对于其他两个PPA变体，我们观察到lvPPA患者中ApoE epsilon 4等位基因的频率更高。在lvPPA患者的C-11 PiB-PET中，在额叶，颞叶，顶叶和后扣带中发现了PiB阳性结果，AD可能会积聚大量A beta。我们在lvPPA患者中包括A beta 1-38和C-11 PiB-PET在内的AD-CSF标记物的结果证明了AD发生的常见病理机制。

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