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首页> 外文期刊>Amyloid: the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis >Trend toward improved day 100 and two-year survival following stem cell transplantation for AL: a comparison before and after 2006.
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Trend toward improved day 100 and two-year survival following stem cell transplantation for AL: a comparison before and after 2006.

机译:AL干细胞移植后第100天和两年生存期改善的趋势:2006年前后的比较。

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摘要

We report 422 patients transplanted for light chain amyloidosis. Day-100 all-cause mortality has fallen from 12% prior to 1 January 2006 to 7% after 1 January 2006 (p = 0.09). Survival at 2 years has likewise improved from 78 to 82%. Serum troponin T and NT-proBNP were the only predictors of early mortality. Refined patient selection has improved the safety margin for patients undergoing high-dose therapy, and therapy-related mortality has been reduced by 40%.
机译:我们报告了422例因轻链淀粉样变性而移植的患者。第100天的全因死亡率已从2006年1月1日之前的12%下降到2006年1月1日之后的7%(p = 0.09)。 2年生存率也从78%提高到82%。血清肌钙蛋白T和NT-proBNP是早期死亡率的唯一预测指标。精致的患者选择提高了接受大剂量治疗的患者的安全裕度,并且与治疗相关的死亡率降低了40%。

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