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首页> 外文期刊>Amyloid: the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis >Amyloid goiter and hypopituitarism in a patient with systemic amyloidosis.
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Amyloid goiter and hypopituitarism in a patient with systemic amyloidosis.

机译：系统性淀粉样变性病患者的淀粉样甲状腺肿和垂体功能低下。

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Systemic amyloidosis may infiltrate the thyroid or other endocrine glands but rarely causes endocrine dysfunction. We describe a 45 years old female patient with diffusely enlarged goiter and hypopituitarism secondary to amyloid infiltration of the thyroid gland and possibly pituitary gland, respectively. She was on chronic haemodialysis for 3 years due to systemic amyloidosis. While she was being prepared for thyroidectomy, adrenal failure developed. Her anterior pituitary hormone levels were low and magnetic resonance imaging of the hypophysis showed low signal intensity in right part of the adenohypophysis. She improved with corticosteroid replacement therapy and underwent subtotal thyroidectomy without any complication. Histopathologically, amyloid deposition was demonstrated in the thyroid gland. To our knowledge, this is the first case with amyloid goiter and hypopituitarism secondary to systemic amyloidosis. Amyloid infiltration should be considered in a systemic amyloidosis patient presenting with rapidly enlarged thyroid gland and signs of hypopituitarism.
机译：系统性淀粉样变性可浸润甲状腺或其他内分泌腺，但很少引起内分泌功能障碍。我们描述了一名45岁的女性患者，其甲状腺肿和可能垂体的淀粉样蛋白浸润分别继发于甲状腺肿和甲状腺肿。由于全身性淀粉样变性，她进行了3年的慢性血液透析。当她准备进行甲状腺切除术时，肾上腺衰竭发展了。她的垂体前叶激素水平低，并且垂体的磁共振成像显示腺垂体的右侧信号强度低。她接受皮质类固醇替代疗法改善，并进行了甲状腺次全切除术，无任何并发症。在组织病理学上，在甲状腺中显示出淀粉样蛋白沉积。据我们所知，这是继发于系统性淀粉样变性病的淀粉样甲状腺肿和垂体功能低下的首例病例。全身性淀粉样变性病患者出现甲状腺快速增大和垂体功能减退的迹象时，应考虑淀粉样蛋白浸润。

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