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首页> 外文期刊>Amyloid: the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis >Hemodynamic responses after tilt reversal in FAP.
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Hemodynamic responses after tilt reversal in FAP.

机译：FAP倾斜反转后的血流动力学反应。

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The aim of the study was to evaluate hemodynamic responses after tilt reversal in familial amyloid polyneuropathy (FAP). Systolic blood pressure (BP) and heart rate variability (HRV) were analyzed in the baseline, 70-degree upright position, and after tilt reversal in 10 patients with FAP and 14 healthy controls. Maximum systolic BP after tilt reversal was increased in FAP as compared to baseline (BP overshoot), whereas controls showed a significantly lower BP overshoot. In all states, all HRV parameters were significantly lower than those of the controls. In a linear regression analysis adjusted for age, we found a significant inverse relation between BP overshoot and HRV in all three states. Five patients presented atrial arrhythmia precluding HRV analysis: four of those presented BP overshoots >12 mmHg. BP overshoot may be a useful marker to assess the progression of cardiac autonomic dysfunction, especially since heart arrhythmia in many patients with FAP prevents HRV analysis.
机译：这项研究的目的是评估家族性淀粉样多发性神经病（FAP）倾斜逆转后的血流动力学反应。在10名FAP患者和14名健康对照者的基线，70度直立位置以及俯仰反转后，分析了收缩压（BP）和心率变异性（HRV）。与基线（BP超调）相比，FAP倾斜反转后的最大收缩压增加（BP超调），而对照组则显示出明显更低的BP超调。在所有状态下，所有HRV参数均显着低于对照组。在针对年龄进行调整的线性回归分析中，我们发现在所有三种状态下，BP超调与HRV之间均存在显着的反比关系。五例患者出现心律失常，未进行HRV分析：其中四例出现BP超调> 12 mmHg。 BP超调可能是评估心脏自主神经功能障碍进展的有用标志，尤其是因为许多FAP患者的心律不齐会阻止HRV分析。

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