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首页> 外文期刊>Amyloid: the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis >Spinal cord stimulation markedly ameliorated refractory neuropathic pain in transthyretin Val30Met familial amyloid polyneuropathy.
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Spinal cord stimulation markedly ameliorated refractory neuropathic pain in transthyretin Val30Met familial amyloid polyneuropathy.

机译：脊髓刺激显着改善了运甲状腺素蛋白Val30Met家族性淀粉样蛋白多神经病的难治性神经性疼痛。

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摘要

Although spinal cord stimulation has been reported to be effective for controlling neuropathic pain in diabetic neuropathy, it has rarely been investigated in other peripheral neuropathies. We describe, for the first time, the efficacy of spinal cord stimulation for refractory neuropathic pain in a patient with transthyretin Val30Met associated familial amyloid polyneuropathy (FAP ATTR Val30Met). A 72-year-old man was diagnosed as having FAP ATTR Val30Met when he was 70 years old. He had been complained of burning pain in the distal portion of his bilateral lower limbs since he was 69 years old. Because conventional symptomatic therapies, including nonsteroidal anti-inflammatory drugs, antiepileptic drugs, and tricyclic antidepressants did not ameliorate pain, he underwent bilateral lumbar spinal cord electrical stimulation at high frequency and low voltage at the level of Th12 vertebral body and this was markedly effective. Our case expands the application of spinal cord stimulation, which should be considered as an alternative therapeutic approach for relief of neuropathic pain, which can be extremely distressful for patients and may lead to an impaired quality of life.
机译：尽管据报道脊髓刺激可有效控制糖尿病性神经病的神经性疼痛，但很少在其他周围神经病中进行研究。我们首次描述了转甲状腺素蛋白Val30Met相关家族性淀粉样蛋白多神经病（FAP ATTR Val30Met）患者难治性神经性疼痛的脊髓刺激疗效。一名72岁的男子在70岁时被诊断患有FAP ATTR Val30Met。自从他69岁以来，他一直抱怨双下肢的远端灼痛。由于包括非甾体类抗炎药，抗癫痫药和三环类抗抑郁药在内的常规对症治疗均未缓解疼痛，因此他在Th12椎体水平上高频和低压下对双侧腰椎脊髓电刺激，效果显着。我们的案例扩大了脊髓刺激的应用，应将脊髓刺激视为缓解神经性疼痛的另一种治疗方法，这可能会使患者极度痛苦，并可能导致生活质量下降。

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