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Health Effects of Diesel Exhaust and Diesel Exhaust Particles

机译：柴油气排气和柴油排气粒子的健康效果

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We had examined the health effects of diesel exhaust (DE) and diesel exhaust particles (DEP). DEP contains a vast number of organic compounds such as polyaromatic hydrocarbons (PAHs) and quinone like compounds. DE and DEP caused essential characteristics of asthma such as chronic airway inflammation (accompanied by infiltration of eosinophils), mucus hypersecretion and airway hyper reactivity, via non-allergic or allergic reactions. It was suggested that active oxygen species were involved in non-allergic airway inflammation. On the other hand, it was suggested that IL-S production via Th2 cells and IgG1 formation were involved in allergic reaction. Furthermore, it was found that DE inhalation caused the decreased the numbers of daily sperm production. Abortion and teratogenic changes were also induced by mating between male mice exposed to DE and non-treated female mice. The main cause of the abortion and treatogenic changes may be due to the organic compounds in DEP.
机译：我们研究过柴油排气（DE）和柴油排气颗粒（DEP）的健康效果。 DEM含有大量的有机化合物，例如聚芳族烃（PAH）和醌如化合物。 DE和DEP造成哮喘的基本特征，如慢性气道炎症（伴有嗜酸性粒细胞渗透），粘液过度分泌和气道超反应性，通过非过敏反应或过敏反应。 建议活性氧物种参与非过敏气道炎症。 另一方面，建议通过TH2细胞和IgG1形成的IL-S产生参与过敏反应。 此外，发现De吸入导致降低日药的数量。 通过在暴露于DE和未处理的雌性小鼠的雄性小鼠之间交配杂交和致畸变化。 流产和治疗变化的主要原因可能是由于DEP中的有机化合物。

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