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首页> 外文期刊>Amyotrophic lateral sclerosis eofficial publication of the World Federation of Neurology Research Group on Motor Neuron Diseases >Percutaneous nocturnal oximetry in amyotrophic lateral sclerosis:Periodic desaturation
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Percutaneous nocturnal oximetry in amyotrophic lateral sclerosis:Periodic desaturation

机译：肌萎缩性侧索硬化的经皮夜间血氧饱和度测定：周期性去饱和

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Percutaneous nocturnal oximetry (PNO) is useful to screen respiratory function in amyotrophic lateral sclerosis (ALS).PNO recordings of some patients disclose a periodical pattern of 02 desaturation (PP), whose significance is unknown. Weaimed to characterize PP pattern, and we used a prospective study enrolling 261 consecutive ALS patients. Clinical,pulmonary and neurophysiological tests performed included: ALS functional rating scale, forced vital capacity (FVC),maximal inspiratory pressure (Plmax), mouth occlusion pressure (MOP), phrenic nerve motor response, needleelectromyography of the diaphragm, PNO, and sleep study. A total of 837 PNO recordings were analysed (3.2recordings/patient) and 45 patients showed typical PP (17.2%). Four were excluded, 13 had normal diaphragm (group1, G1), and in 28 the diaphragm was abnormal (G2). The two groups were comparable, apart from respiratory score, FVCand Plmax which were lower in G2. In GI, REM sleep was absent and hypoventilation occurred at slow-wave sleep. Fivepatients in GI were very spastic, had low MOP/FVC and a short survival. This study identified a subgroup of ALS patients(G1) with marked signs of upper motor neuron lesion, strong respiratory muscles, PP, low MOP/FVC ratio and poorprognosis. We speculate that they have a central respiratory dysfunction and deserve special care.
机译：经皮夜间血氧饱和度测定法（PNO）可用于筛查肌萎缩性侧索硬化症（ALS）的呼吸功能。一些患者的PNO记录揭示了02饱和度降低（PP）的周期性模式，其意义尚不清楚。我们无意描述PP模式，并且我们使用了一项前瞻性研究，招募了261名连续的ALS患者。进行的临床，肺和神经生理学测试包括：ALS功能评定量表，强制肺活量（FVC），最大吸气压力（Plmax），口闭塞压力（MOP），en神经运动反应，隔膜肌电图，PNO和睡眠研究。共分析了837例PNO记录（每位患者3.2记录），其中45例患者表现出典型的PP（17.2％）。排除了四个，隔膜13个正常（第1组，G1），隔膜28个异常（G2）。除呼吸评分，FVC和Plmax均低于G2以外，两组均相当。在胃肠道，REM睡眠不足，慢波睡眠时出现通气不足。五名胃肠道疾病患者痉挛性强，MOP / FVC低，生存期短。本研究确定了一个ALS患者亚组（G1），该患者具有上运动神经元病变，呼吸肌强健，PP，低MOP / FVC比和预后不良的明显体征。我们推测他们患有中枢性呼吸功能不全，应予以特别护理。

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