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首页> 外文期刊>Anaesthesia and intensive care >Changes in clinical research in anaesthesia and intensive care from 1974-2004.
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Changes in clinical research in anaesthesia and intensive care from 1974-2004.

机译：1974-2004年间麻醉和重症监护临床研究的变化。

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The purpose was to identify how the quality of anaesthesia research has improved from articles published in Anaesthesia and Intensive Care over 25 years. Original papers were included during the periods 1974-1978 and 2000-2004. Each article was classified according to principal research designs and the two five-year periods were compared. All interventional trials were evaluated according to the following a priori criteria: author number; ethics approval; informed consent; competing financial interest; eligibility criteria; sample size calculation; method of randomization; patients accounted for; blind assessment of outcome; adverse outcomes; statistical method stated; type I error; type II error; and anaesthetic department of origin. Comparisons of above criteria were made between the two groups using chi-square test or Fischer's exact test. Two-hundred-and-ninety-two articles were reviewed in 1974-1978 and 529 articles were reviewed in 2000-2004. Animal/laboratory articles decreased from 17.47% to 12.28% (P=0.05). Review articles decreased from 34.35% to 10.4% (P<0.0001). Descriptive trials increased from 28.4% to 52.72% (P<0.0001). Interventional trials increased from 18.84% to 22.31% (P=0.269). Uncontrolled clinical trials decreased from 27.27% to 12.71%, non-randomized controlled trials decreased from 50.91% to 7.63%, and randomized controlled trials increased from 21.82% to 79.66% (P<0.0001). All interventional trials criteria improved and were statistically significant except competing financial interest, method of randomization, patients accounted for; and type II error The quality of anaesthetic research has improved in Anaesthesia and Intensive Care over the past 30 years. However; there is still room for improvement.
机译：目的是确定麻醉研究和重症监护25年来发表的文章如何改善麻醉研究的质量。原始论文包括在1974-1978年和2000-2004年期间。每篇文章都根据主要研究设计进行了分类，并比较了两个五年期。根据以下先验标准评估所有干预性试验：作者人数;道德批准;知情同意;竞争性财务利益;资格标准;样本量计算;随机方法患者占;对结果进行盲目评估;不良结果;统计方法说明; I型错误; II型错误;和麻醉原产地。使用卡方检验或菲舍尔精确检验对两组之间的上述标准进行比较。 1974-1978年审查了292篇文章，2000-2004年审查了529篇文章。动物/实验室用品从17.47％下降至12.28％（P = 0.05）。评论文章从34.35％下降到10.4％（P <0.0001）。描述性试验从28.4％增加到52.72％（P <0.0001）。干预试验从18.84％增加到22.31％（P = 0.269）。非对照临床试验从27.27％降低到12.71％，非随机对照试验从50.91％降低到7.63％，随机对照试验从21.82％增加到79.66％（P <0.0001）。除竞争性经济利益，随机化方法，患者占比外，所有干预性试验标准均得到改善，并且在统计学上具有统计学意义。和II型错误过去30年来，麻醉和重症监护室的麻醉研究质量得到了提高。然而;仍有改进的空间。

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