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首页> 外文期刊>Anaesthesia and intensive care >Potency of mephentermine for prevention of post-spinal hypotension.
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Potency of mephentermine for prevention of post-spinal hypotension.

机译：美芬特明对预防脊髓后低血压的作用。

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This study was designed to determine the minimum effective dose (ED50) of mephentermine for prevention of post-spinal hypotension in women undergoing elective caesarean section. Dixon's up-down method of sequential allocation was used to determine the patient's dose of vasopressor drug. In our previous study, mephentermine appeared to be much more potent than ephedrine, so the present study was conducted using a lower initial dose and smaller dose interval for this vasopressor. Following administration of spinal anaesthesia, a prophylactic infusion of mephentermine was started with 5 mg infused over a period of 30 minutes as the initial dose and a dose interval of 1 mg. The ED50 of mephentermine of 3.7 mg (95% confidence interval 2.4 to 5.7 mg) was much less than that of ephedrine, as calculated in our previous study using the same methodology. Using these values gives a potency ratio of ephedrine to mephentermine of 1:6.8 (95% confidence interval 6.0 to 7.5).
机译：这项研究旨在确定美择特明预防选择性剖腹产妇女脊柱后低血压的最低有效剂量（ED50）。 Dixon的上下分配顺序分配方法用于确定患者的血管加压药剂量。在我们以前的研究中，美芬特明似乎比麻黄碱更有效，因此本研究使用的是这种升压药的较低初始剂量和较小的剂量间隔。进行脊髓麻醉后，开始预防性输注美芬特明，在30分钟内以5 mg初始剂量和1 mg的剂量间隔进行输注。如在我们先前的研究中使用相同方法所计算的，美芬特明的ED50为3.7 mg（95％置信区间为2.4至5.7 mg）远低于麻黄碱。使用这些值可得出麻黄碱与美芬特明的效能比为1：6.8（95％置信区间为6.0至7.5）。

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