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Pharmacogenomics

机译:药物基因组学

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Pharmacogenetics is the study of the effects of particular genes on the variation in drug response and pharmacogenomics is the study of the effects of the whole genome on drug response. There are many examples from anaesthesia where a genetic linkage to response is known. These include cholinesterase and suxamethonium. Genetic variation can occur at all stages in the pharmacological process; pharmacokinetic and phar-macodynamic. The response to morphine can be influenced by, for example, genetic variation in cytochrome P450 (pharmacokinetic) and the x opioid receptor (pharmacodynamic). Understanding and being able to screen for these genetic variations in drug response may enable a more personalized drug use with greater benefit and reduced side effects.
机译:药物遗传学是研究特定基因对药物反应变化的影响,而药物基因组学是研究整个基因组对药物反应的影响。麻醉有许多例子,其中已知与反应的遗传联系。这些包括胆碱酯酶和丁二铵。遗传变异可以发生在药理过程的所有阶段。药代动力学和药动学。对吗啡的反应可能受到例如细胞色素P450(药物动力学)和阿片样物质受体x(药物动力学)的遗传变异的影响。了解并能够筛选出药物反应中的这些遗传变异可以使药物的使用更加个性化,并带来更大的益处并减少副作用。

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