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首页> 外文期刊>American journal of industrial medicine >Response to Dr. Reich's letter: ''Sarcoid-like' granulomatous pulmonary disease in world trade center disaster responders: influence of incidence computation methodology in inferring airborne dust causation': 'Sarcoid-like' granulomatous pulmonary disease in World Trade Center disaster responders.
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Response to Dr. Reich's letter: ''Sarcoid-like' granulomatous pulmonary disease in world trade center disaster responders: influence of incidence computation methodology in inferring airborne dust causation': 'Sarcoid-like' granulomatous pulmonary disease in World Trade Center disaster responders.

机译：对Reich博士的信的答复：“世贸中心灾难响应者中的“类肉瘤”肉芽肿性肺病：发病率计算方法在推断航空尘埃因果关系中的影响”：世贸中心灾难响应者中的“类瘤样肉芽肿性肺病”。

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摘要

Dr. Reich attempts to discount our rinding of increased "Sarcoid-like" granulomatous disease in World Trade Center responders, a pattern of disease that peaked 2-3 years after the attacks of September 11,2001 and then resolved. He argues that our observation reflects a combination of ascertainment bias and accrual of previously unrecognized cases [Reich, 2011]. We disagree with his conclusions for the following six reasons: 1. Our findings are biologically plausible. It is well established that the 9/11 responders faced a complex and unprecedented exposure to airborne dust and debris. Especially those responders who were caught in the dust cloud that rolled through the streets of lower Manhattan on September 11, 2001 inhaled massive quantities of particulate matter, large and small, into their airways and their lungs. Airborne concentrations were so high that they overwhelmed all normal physiological defense mechanisms. Bronchoscopies performed on September 11 responders have documented the presence of large particles deep in their lungs.
机译：Reich博士试图消除我们对世贸中心响应者中增加的“类瘤样”肉芽肿病的浸润，这种疾病的模式在2001年9月11日袭击后的2-3年达到顶峰，然后得以解决。他认为，我们的观察结果反映了确定性偏见和先前无法识别的病例的应计[Reich，2011]。由于以下六个原因，我们不同意他的结论：1.我们的发现在生物学上是合理的。众所周知，9/11响应者面临着空前尘埃和碎屑的复杂而前所未有的暴露。尤其是那些被2001年9月11日在曼哈顿下城的街道上滚动的尘埃云所吸引的响应者，将大量大小不一的微粒物质吸入其气道和肺部。空气中的浓度很高，以至于压倒了所有正常的生理防御机制。 9月11日响应者进行的支气管镜检查已证明其肺部深处存在大颗粒。

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