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首页> 外文期刊>Animal Science Journal >Effects of amino acids infused into the vein on ghrelin-induced GH, insulin and glucagon secretion in lactating cows.
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Effects of amino acids infused into the vein on ghrelin-induced GH, insulin and glucagon secretion in lactating cows.

机译：静脉内注入氨基酸对泌乳母牛生长素释放肽诱导的GH，胰岛素和胰高血糖素分泌的影响。

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摘要

To investigate the effects of amino acids on ghrelin-induced growth hormone (GH), insulin and glucagon secretion in lactating dairy cattle, six Holstein cows were randomly assigned to two infusion treatments in a cross-over design. Mixture solution of amino acids (AMI) or saline (CON) was continuously infused into the left side jugular vein via catheter for 4 h. At 2 h after the start of infusion, synthetic bovine ghrelin was single injected into the right side jugular vein through the catheter. Ghrelin injection immediately increased plasma GH, glucose and non-esterified fatty acids (P<0.05) with no difference between both treatments. Additionally, plasma insulin and glucagon concentrations were increased by ghrelin injection in both treatments. The peak value of plasma insulin concentration was greater in AMI compared with CON (P<0.05). Plasma glucagon concentration showed no difference in the peak value reached at 5 min between both treatments, and then the plasma levels in AMI compared with CON showed sustained higher values (P<0.05). After plasma glucose concentration reached the peak, the decline was greater in AMI compared with CON (P<0.05). These results showed that the increased plasma amino acids may enhance ghrelin action which in turn enhances insulin and glucagon secretions in lactating cows.
机译：为了研究氨基酸对泌乳奶牛生长激素释放肽诱导的生长激素（GH），胰岛素和胰高血糖素分泌的影响，以交叉设计将6头荷斯坦奶牛随机分配给两种输液治疗。通过导管将氨基酸（AMI）或生理盐水（CON）的混合溶液连续注入左侧颈静脉，持续4 h。输注开始后2小时，通过导管将合成牛生长素释放肽单次注入右侧颈静脉。 Ghrelin注射立即增加血浆GH，葡萄糖和非酯化脂肪酸（ P <0.05），两种治疗之间无差异。另外，在两种治疗中，通过生长素释放肽注射增加血浆胰岛素和胰高血糖素的浓度。 AMI患者血浆胰岛素浓度的峰值高于CON（ P <0.05）。两种处理之间的血浆胰高血糖素浓度均未显示在5分钟时达到峰值，然后与CON相比，AMI中的血浆水平显示出持续较高的值（ P <0.05）。血浆葡萄糖浓度达到峰值后，AMI的下降幅度大于CON（ P <0.05）。这些结果表明，增加的血浆氨基酸可增强生长素释放肽的作用，进而增强泌乳母牛的胰岛素和胰高血糖素分泌。

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