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Chemical-Biological Studies of Subcellular Organization in Bacteria

机译:细菌亚细胞组织的化学 - 生物学研究

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摘要

The subcellular organization of biological molecules is a critical determinant of many bacterial processes, including growth, replication of the genome, and division, yet the details of many mechanisms that control intracellular organization remain unknown. Decoding this information will impact the field of bacterial physiology and can provide insight into eukaryotic biology, including related processes in mitochondria and chloroplasts. Small molecule probes provide unique advantages in studying these mechanisms and manipulating the organization of biomolecules in live bacterial cells. In this review, we describe small molecules that are available for investigating subcellular organization in bacteria, specifically targeting FtsZ, MreB, peptidoglycan, and lipid bilayers. We discuss how these probes have been used to study microbiological questions and conclude by providing suggestions about important areas in which chemical biological approaches will have a revolutionary impact on the study of bacterial physiology.
机译:生物分子的亚细胞组织是许多细菌方法的关键决定因素,包括生长,基因组的复制,以及划分,但控制细胞内组织的许多机制的细节仍然未知。解码此信息将影响细菌生理领域,并可以提供对真核生物学的洞察力,包括线粒体和叶绿体中的相关过程。小分子探针在研究这些机制和操纵生物细胞中的生物分子组织方面提供独特的优势。在本文中,我们描述了可用于研究细菌中的亚细胞组织的小分子,特别是针对FTSZ,MREB,肽聚糖和脂双层。我们讨论这些探针如何通过提供有关化学生物方法对细菌生理学研究的革命性影响的重要领域的建议来研究微生物问题和得出结论。

著录项

  • 来源
    《Biochemistry》 |2011年第36期|共16页
  • 作者

    Foss MH; Eun YJ; Weibel DB;

  • 作者单位

    Department of Biochemistry University of Wisconsin Madison Wisconsin 53706 United States;

    Department of Biochemistry University of Wisconsin Madison Wisconsin 53706 United States;

    Department of Biochemistry University of Wisconsin Madison Wisconsin 53706 United States;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物化学;
  • 关键词

    information; subcellular organization; microbiological;

    机译:信息;亚细胞组织;微生物学;

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