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Refining humane end points in mouse irradiation studies

机译：在小鼠辐射研究中完善人性化的终点

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摘要

With increasing interest in stem cells and gene function in cell biology, there has been an increase in experimental protocols which involve the whole body irradiation of mice. In these techniques the recipient mouse is exposed to a dose of radiationthat destroys its bone marrow before receiving a transplant of bone marrow progenitor cells from a donor animal or embryo. If the transplant is successful the progenitor BM cells from the donor animal will establish a new haematopoietic system in the recipient mouse. The development of the transplanted bone marrow can be followed by serial blood sampling or bone marrow biopsy. It is important that enough of the host animal's bone marrow is destroyed to allow the transplanted cells to implant and developin the vacant niche. If the recipient mouse was not "rescued" by the BM transplant then it would die from failure of its bone marrow as a result of exposure to the radiation.
机译：随着对干细胞的兴趣和细胞生物学中基因功能的增加，涉及小鼠全身照射的实验方案也有所增加。在这些技术中，受体小鼠在接受来自供体动物或胚胎的骨髓祖细胞移植之前，暴露于一定剂量的辐射下会破坏其骨髓。如果移植成功，则来自供体动物的祖细胞将在受体小鼠体内建立新的造血系统。移植骨髓的发育可以随后进行连续血液采样或骨髓活检。重要的是要破坏足够多的宿主动物的骨髓，以使移植的细胞能够在空位中植入并发育。如果受体小鼠没有被BM移植“拯救”，那么它将因暴露于放射线而导致骨髓衰竭而死亡。

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