...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biochemistry >Mechanochemistry in Translation
【24h】

Mechanochemistry in Translation

机译：在翻译中的技工

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

As the influence of translation rates on protein folding and function has come to light, the mechanisms by which translation speed is modulated have become an important issue. One mechanism entails the generation of force by the nascent protein. Cotranslational processes, such as nascent protein folding, the emergence of unfolded nascent chain segments from the ribosome's exit tunnel, and insertion of the nascent chain into or translocation of the nascent chain through membranes, can generate forces that are transmitted back to the peptidyl transferase center and affect translation rates. In this Perspective, we examine the processes that generate these forces, the mechanisms of transmission along the ribosomal exit tunnel to the peptidyl transferase center, and the effects of force on the ribosome's catalytic cycle. We also discuss the physical models that have been developed to predict and explain force generation for individual processes and speculate about other processes that may generate forces that have yet to be tested.
机译：随着翻译率对蛋白质折叠和功能的影响，调制翻译速度的机制已成为一个重要问题。一种机制需要由新生蛋白产生武力。诸如新生蛋白质折叠的分类过程，从核糖体的出口隧道中出现展开的新生链段，并将新生链子插入或通过膜插入或旋转进入膜，可以产生透射回肽基转移酶中心的力并影响翻译率。在这种观点中，我们检查产生这些力的过程，沿核糖体出口隧道传递到肽基转移酶中心的机制，以及力对核糖体催化循环的影响。我们还讨论已经开发的物理模型，以预测各个过程的强制生成，并推测可能产生尚未测试的力的其他过程。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号