Redox Kinetics of the Amyloid-beta-Cu Complex and Its Biological Implications

Girvan Paul; Teng Xiangyu; Brooks Nicholas J.; Baldwin Geoffrey S.; Ying Liming

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Redox Kinetics of the Amyloid-beta-Cu Complex and Its Biological Implications

机译：淀粉样蛋白β-Cu复合物的氧化还原动力学及其生物学意义

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The ability of the amyloid-beta peptide to bind to redox active metals and act as a source of radical damage in Alzheimer's disease has been largely accepted as contributing to the disease's pathogenesis. However, a kinetic understanding of the molecular mechanism, which underpins this radical generation, has yet to be reported. Here we use a sensitive fluorescence approach, which reports on the oxidation state of the metal bound to the amyloid-beta peptide and can therefore shed light on the redox kinetics. We confirm that the redox goes via a low populated, reactive intermediate and that the reaction proceeds via the Component I coordination environment rather than Component II. We also show that while the reduction step readily occurs (on the 10 ms time scale) it is the oxidation step that is rate-limiting for redox cycling.

机译：淀粉样蛋白β肽与氧化还原活性金属结合的能力并充当阿尔茨海默病患者疾病的根治伤害源，这主要被认为是有助于疾病的发病机制。然而，尚未报告对该激进生成的分子机制的动力学理解。在这里，我们使用敏感的荧光方法，其报告了与淀粉样蛋白β肽结合的金属的氧化状态，因此可以在氧化还原动力学上脱落。我们确认氧化还原通过低填充的反应中间体进行，并且反应通过组件I协调环境而不是组件II进行。我们还表明，虽然减少步骤易于发生（在10ms的时间尺度上）是氧化步骤，其是氧化还原循环的速率限制。

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《Biochemistry》 |2018年第43期|共6页
作者
Girvan Paul; Teng Xiangyu; Brooks Nicholas J.; Baldwin Geoffrey S.; Ying Liming;
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作者单位

Imperial Coll London Dept Chem London SW7 2AZ England;

Imperial Coll London Dept Chem London SW7 2AZ England;

Imperial Coll London Dept Chem London SW7 2AZ England;

Imperial Coll London Inst Chem Biol London SW7 2AZ England;

Imperial Coll London Inst Chem Biol London SW7 2AZ England;

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正文语种 eng
中图分类生物化学;
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1. Redox Kinetics of the Amyloid-beta-Cu Complex and Its Biological Implications [J] . Girvan Paul, Teng Xiangyu, Brooks Nicholas J., Biochemistry . 2018,第43期

机译：淀粉样蛋白β-Cu复合物的氧化还原动力学及其生物学意义
2. Redox Kinetics of the Amyloid-beta-Cu Complex and Its Biological Implications [J] . Girvan Paul, Teng Xiangyu, Brooks Nicholas J., Biochemistry . 2018,第43期

机译：淀粉样蛋白β-Cu复合物的氧化还原动力学及其生物学意义
3. Exploring the Strength, Mode, Dynamics, and Kinetics of Binding Interaction of a Cationic Biological Photosensitizer with DNA: Implication on Dissociation of the Drug-DNA Complex via Detergent Sequestration [J] . Bijan Kumar Paul, Nikhil Guchhait The journal of physical chemistry, B. Condensed matter, materials, surfaces, interfaces & biophysical . 2011,第41期

机译：探索阳离子生物光敏剂与DNA的结合相互作用的强度，模式，动力学和动力学：对药物-DNA复合物通过洗涤剂螯合解离的影响
4. Development of a rapid LC-MS method to analyze polar metabolites in complex biological samples; a prelude to kinetic flux profiling [C] . Jay S. Kirkwood, Corey D. Broeckling, Jordan Steel, ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：一种快速LC-MS方法的开发，分析复杂生物样品中北极代谢物;动力通量分析的前奏
5. THE HEXAVALENT ACTINIDES: SOME NEW DIRECTIONS IN THE STUDY OF REDOX KINETICS AND COMPLEXATION THERMODYNAMICS. [D] . BERTRAND, PEGGY ANN. 1982

机译：六价系：氧化还原动力学和复杂热力学研究中的一些新方向。
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机译：约束供体原子取向对大环多醚络合物稳定性，络合动力学，氧化还原电位和结构的影响。铜（II）铜（II）与80％甲醇中14 Anes4的环戊烷二基衍生物的复合物

Redox Kinetics of the Amyloid-beta-Cu Complex and Its Biological Implications

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