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首页> 外文期刊>Biochemistry >Structural Mechanisms of Gating in Ionotropic Glutamate Receptors
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Structural Mechanisms of Gating in Ionotropic Glutamate Receptors

机译：离子型谷氨酸受体中浇注的结构机制

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摘要

Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate the majority of excitatory neurotransmission in the central nervous system. iGluRs open their ion channels in response to binding of the neurotransmitter glutamate, rapidly depolarize the postsynaptic neuronal membrane, and initiate signal transduction. Recent studies using X-ray crystallography and cryo-electron microscopy have determined full-length iGluR structures that (1) uncover the receptor architecture in an unliganded, resting state, (2) reveal conformational changes produced by ligands in order to activate iGluRs, open their ion channels, and conduct ions, and (3) show how activated, glutamate-bound iGluRs can adopt a nonconducting desensitized state. These new findings, combined with the results of previous structural and functional experiments, kinetic and molecular modeling, mutagenesis, and biochemical analyses, provide new views on the structural mechanisms of iGluR gating.
机译：离子型谷氨酸受体（IGLURS）是配体门控离子通道，其介导中枢神经系统中大多数兴奋性神经递血。 iglurs响应于神经递质谷氨酸的结合而打开它们的离子通道，快速地去极化突触后神经元膜，并引发信号转导。 使用X射线晶体学和冷冻电子显微镜的最近的研究具有确定的全长IGLUR结构，该全长IGLUR结构（1）在释放的休息状态下揭示受体架构，（2）揭示配体产生的构象变化以便激活IGLUR，打开 它们的离子通道和导电离子和（3）显示了如何激活谷氨酸结合的iglurs可以采用非导电的脱敏状态。 这些新发现与先前结构和功能实验的结果相结合，动力学和分子建模，诱变和生化分析，对IGLUR门控的结构机制提供了新的视图。

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  • 来源
    《Biochemistry》 |2018年第3期|共10页
  • 作者

    Edward C. Twomey; Alexander I. Sobolevsky;

  • 作者单位

    Department of Biochemistry and Molecular Biophysics and Integrated Program in Cellular Molecular and Biomedical Studies Columbia University 650 West 168th Street New York New York 10032 United States;

    Department of Biochemistry and Molecular Biophysics and Integrated Program in Cellular Molecular and Biomedical Studies Columbia University 650 West 168th Street New York New York 10032 United States;

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  • 正文语种 eng
  • 中图分类 生物化学;
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