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Spatial Organization of Metabolic Enzyme Complexes in Cells

机译:细胞中代谢酶复合物的空间组织

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摘要

The organization of metabolic multienzyme complexes has been hypothesized to benefit metabolic processes and provide a coordinated way for the cell to regulate metabolism. Historically, their existence has been supported by various in vitro techniques. However, it is only recently that the existence of metabolic complexes inside living cells has come to light to corroborate this long-standing hypothesis. Indeed, subcellular compartmentalization of metabolic enzymes appears to be widespread and highly regulated. On the other hand, it is still challenging to demonstrate the functional significance of these enzyme complexes in the context of the cellular milieu. In this review, we discuss the current understanding of metabolic enzyme complexes by primarily focusing on central carbon metabolism and closely associated metabolic pathways in a variety of organisms, as well as their regulation and functional contributions to cells.
机译:已经假设代谢偏酶复合物组织以使代谢过程有益,并为细胞提供调节代谢的协调方法。 从历史上看,他们的存在是通过各种体外技术支持的。 然而,最近,唯一的是,活细胞内部代谢复合物的存在已经阐明了这种长期假设。 实际上,代谢酶的亚细胞间隔似乎是普遍的和高度调节的。 另一方面,证明这些酶络合物在细胞环境中的这些酶复合物的功能意义仍然具有挑战性。 在本文中,我们通过主要关注中央碳代谢和各种生物中的密切相关的代谢途径以及它们对细胞的调节和功能贡献来讨论对代谢酶复合物的目前的理解。

著录项

  • 来源
    《Biochemistry》 |2017年第25期|共13页
  • 作者

    Schmitt Danielle L.; An Songon;

  • 作者单位

    Univ Maryland Baltimore Cty Dept Chem &

    Biochem 1000 Hilltop Circle Baltimore MD 21250 USA;

    Univ Maryland Baltimore Cty Dept Chem &

    Biochem 1000 Hilltop Circle Baltimore MD 21250 USA;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物化学;
  • 关键词

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