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首页> 外文期刊>Biomaterials >The role of miR-31-modified adipose tissue-derived stem cells in repairing rat critical-sized calvarial defects
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The role of miR-31-modified adipose tissue-derived stem cells in repairing rat critical-sized calvarial defects

机译：miR-31改性的脂肪组织衍生干细胞在修复大鼠临界大小的颅骨缺陷中的作用

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It is still difficult to repair critical-sized defects (CSDs) following trauma or tumor resection in the clinic. Autografts, which are osteoconductive and osteoinductive, set the gold standard for the clinical repair of bone defects. However, the disadvantages include infection, pain, loss of function and restricted supply due to donor shortage and morbidity [1]. With the recent development of materials and gene therapy, tissue engineering technology has become one of the most promising therapeutic approaches for bone regeneration in bone defects [2e4]. Due to their function in stimulating stem cell osteogenesis and angiogenesis, growth factors play an important role when tissue-engineered bone is used to repair a bone defect. Previous studies demonstrated that many factors, such as bone morphogenic proteins (BMPs), vascular endothelial growth factor (VEGF), hypoxia-inducible factor-1 a (HIF-1a) and basic fibroblast growth factor (bFGF), can stimulate osteogenesis and angiogenesis in bone defects using a local gene-enhanced tissue-engineering method [4e6].
机译：在诊所的创伤或肿瘤切除后仍然难以修复关键尺寸的缺陷（CSD）。自体移植物，即易发电和骨诱导，设定了骨缺损临床修复的金标准。然而，缺点包括感染，疼痛，功能损失和因供体短缺和发病率的限制供应[1]。随着最近的材料和基因治疗的发展，组织工程技术已成为骨缺损中骨再生的最有希望的治疗方法之一[2e4]。由于它们在刺激干细胞骨质发生和血管生成的作用，生长因子在组织工程骨用于修复骨缺陷时发挥着重要作用。以前的研究表明，许多因素，例如骨形态发生蛋白（BMP），血管内皮生长因子（VEGF），缺氧诱导因子-1a（HIF-1A）和碱性成纤维细胞生长因子（BFGF）可以刺激成骨和血管生成使用局部基因增强组织工程方法的骨缺损[4e6]。

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