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首页> 外文期刊>Biomaterials >A magnetic chitosan hydrogel for sustained and prolonged delivery of Bacillus Calmette-Guérin in the treatment of bladder cancer
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A magnetic chitosan hydrogel for sustained and prolonged delivery of Bacillus Calmette-Guérin in the treatment of bladder cancer

机译：一种磁性壳聚糖水凝胶，用于治疗膀胱癌的Bacillus Calmette-guérin持续和长时间递送

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摘要

The aim of this study was to develop a magnetic thermosensitive hydrogel as intravesical Bacillus Calmette-Guérin (BCG) delivery system, which was formulated with chitosan (CS), β-glycerophosphate (GP) and Fe3O4 magnetic nanoparticle (Fe3O4-MNP). The gelation time and magnetic response of the gel system were investigated. The morphology of the gel was displayed by scanning electron microscope. Frozen section examination was creatively employed for exhibiting the structure of the gel and determining its intravesical residence time. The antitumor effect and local immune activity of BCG loaded magnetic gel were evaluated. The flowing solution of CS/GP under room temperature could gelate rapidly at body temperature both invitro and invivo. The magnetic injectable hydrogels significantly prolonged intravesical BCG residence time under an applied magnetic field. In comparison to traditional BCG therapy for superficial bladder tumor, BCG delivered by the gel system induced a stronger Th1 immune response and revealed higher antitumor efficacy.
机译：该研究的目的是开发磁热敏水凝胶作为膀胱内芽孢杆菌（BCG）输送系统，其用壳聚糖（Cs），β-甘油（GP）和Fe3O4磁性纳米颗粒（Fe3O4-MNP）配制。研究了凝胶系统的凝胶化时间和磁响应。通过扫描电子显微镜显示凝胶的形态。冻结剖面检查是创造性地用于表现出凝胶结构并确定其膀胱内停留时间。评估了BCG负​​载磁性凝胶的抗肿瘤效应和局部免疫活性。室温下Cs / GP的流动溶液在体温下吞噬invitro和invivo可以凝胶化。磁性可注射水凝胶在施加的磁场下显着延长介质的BCG停留时间。与传统的BCG治疗浅表膀胱肿瘤，BCG由凝胶系统赋予较强的TH1免疫应答，并揭示了较高的抗肿瘤功效。

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  • 来源
    《Biomaterials》 |2013年第38期|共9页
  • 作者

    ZhangD.; SunP.; LiP.; XueA.; ZhangX.; ZhangH.; JinX.;

  • 作者单位

    Minimally Invasive Urology Center Shandong Provincial Hospital Affiliated to Shandong University;

    Minimally Invasive Urology Center Shandong Provincial Hospital Affiliated to Shandong University;

    Minimally Invasive Urology Center Shandong Provincial Hospital Affiliated to Shandong University;

    Minimally Invasive Urology Center Shandong Provincial Hospital Affiliated to Shandong University;

    Electron Microscope Laboratory College of Physics and Electronics Shandong Normal University;

    Minimally Invasive Urology Center Shandong Provincial Hospital Affiliated to Shandong University;

    Minimally Invasive Urology Center Shandong Provincial Hospital Affiliated to Shandong University;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物医学工程;
  • 关键词

    Bacillus Calmette-Guérin; Chitosan; Intravesical drug delivery; Intravesical instillation; Magnetic nanoparticle; Thermosensitive hydrogel;

    机译：Bacillus calmette-guérin;壳聚糖;膀胱内脏输送;膀胱内滴注;磁性纳米粒子;热敏水凝胶;

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