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首页> 外文期刊>Biomaterials >ECM modulated early kidney development in embryonic organ culture
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ECM modulated early kidney development in embryonic organ culture

机译：ECM调节胚胎器官文化中的早期肾发育

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Prospects for the treatment of severely injured kidneys, kidney failure or chronic kidney disease are currently limited. Therefore, new therapies to recover renal function are an important clinical objective motivating research for regenerative medical strategies. Most of these approaches rely on the use of stem and progenitor cells, which are either directly injected [1,2], or transplanted as pre-differentiated tissue [3e7]. Regenerative therapies require an in-depth understanding of development, maintenance, turnover and repair of the respective organ. Organ and tissue culture techniques are increasingly receiving attention and are used to cultivate material from both embryonic and adult origin [8e11]. In contrast to conventional cell culture, were only one or few cell types are cultured simultaneously, these approaches can provide additional insights into the development of organs and tissues. As a specific cluster of different cells with their specialized ECM is explanted for the use in organ or tissue culture, the in vivo situation is resembled for the most part while these approaches are still in vitro methods with the advantage of easy experimental accessibility.
机译：目前有限地有限地治疗严重受伤的肾脏，肾功能衰竭或慢性肾病的前景。因此，新的回收肾功能的新疗法是再生医学策略的重要临床目标激励研究。这些方法中的大多数依赖于使用茎和祖细胞，其直接注射[1,2]，或者移植为预分化的组织[3e7]。再生疗法需要深入了解各种器官的开发，维护，营业额和修复。器官和组织培养技术越来越受到关注，并且用于培养来自胚胎和成人来源的材料[8e11]。与常规细胞培养相反，仅同时培养一种或几种细胞类型，这些方法可以提供额外的洞察器官和组织的发育。作为使用其专业ECM的不同细胞的特定细胞的特定簇被剥夺在器官或组织培养中，在大部分情况下，在大部分情况下，这些方法仍然具有易于实验可接受性的优势的体外方法。

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