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Injectable, porous, and cell-responsive gelatin cryogels

机译：可注射的，多孔和细胞响应明胶冷冻胶质

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摘要

The performance of biomaterials-based therapies can be hindered by complications associated with surgical implant, motivating the development of materials systems that allow minimally invasive introduction into the host. In this study, we created cell-adhesive and degradable gelatin scaffolds that could be injected through a conventional needle while maintaining a predefined geometry and architecture. These scaffolds supported attachment, proliferation, and survival of cells invitro and could be degraded by recombinant matrix metalloproteinase-2 and -9. Prefabricated gelatin cryogels rapidly resumed their original shape when injected subcutaneously into mice and elicited only a minor host response following injection. Controlled release of granulocyte-macrophage colony-stimulating factor from gelatin cryogels resulted in complete infiltration of the scaffold by immune cells and promoted matrix metalloproteinase production leading to cell-mediated degradation of the cryogel matrix. These findings suggest that gelatin cryogels could serve as a cell-responsive platform for biomaterial-based therapy.
机译：基于生物材料的疗法的性能可以通过与外科手术植入物相关的并发症来阻碍，促使允许微创引入主体的材料系统的发展。在该研究中，我们创造了可以通过传统针注射的细胞粘合剂和可降解的明胶支架，同时保持预定的几何形状和架构。这些支架支持细胞invitro的附着，增殖和存活，并且可以通过重组基质金属蛋白酶-2和-9降解。当皮下注射成小鼠并仅在注射后引发次要宿主响应时，预制的明胶冷冻蛋白在原始形状迅速恢复。从明胶冷冻凝胶的粒细胞 - 巨噬细胞菌落刺激因子的控制释放导致免疫细胞完全渗透支架，并促进了导致细胞介导的细胞介导的细胞介导的降解凝胶基质的产生。这些发现表明明胶冷冻胶可以作为基于生物材料疗法的细胞响应平台。

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  • 来源
    《Biomaterials》 |2014年第8期|共11页
  • 作者

    KoshyS.T.; FerranteT.C.; LewinS.A.; MooneyD.J.;

  • 作者单位

    School of Engineering and Applied Sciences Harvard University Cambridge MA 02138 United States;

    Wyss Institute for Biologically Inspired Engineering Harvard University Boston MA 02115 United;

    Wyss Institute for Biologically Inspired Engineering Harvard University Boston MA 02115 United;

    School of Engineering and Applied Sciences Harvard University Cambridge MA 02138 United States;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物医学工程;
  • 关键词

    Cryogel; Degradable; Gelatin; Injectable; Matrix metalloproteinase;

    机译：cryogel;可降解;明胶;注射;基质金属蛋白酶;

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