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首页> 外文期刊>Biomaterials >Platelet membrane coating coupled with solar irradiation endows a photodynamic nanosystem with both improved antitumor efficacy and undetectable skin damage
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Platelet membrane coating coupled with solar irradiation endows a photodynamic nanosystem with both improved antitumor efficacy and undetectable skin damage

机译：血小板膜涂层与太阳照射耦合赋予光动力纳米系统，具有改善的抗肿瘤功效和不可检测的皮肤损伤

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The therapeutic efficacy of tumor photodynamic therapy (PDT) is hindered by the following three challenges. The extremely short lifetime of reactive oxygen species (ROS, the cytotoxic factor of PDT) limits the radius of their action to tens-of-nanometer scale; functionalizing a photodynamic nanosystem with active targeting moieties helps bring the target cells into reach of ROS but requires extra research efforts. Current photodynamic systems are in general excited by light on the short end of near-infrared (NIR) region; deep tissue penetration necessitates the development of those excitable by longer NIR light. Reducing irradiation dose is necessary for avoiding skin damages but impacts the therapeutic outcome; how to resolve this delimma remains a challenge. We herein show that platelet membrane-coating over a photodynamic nanoparticle coupled with solar irradiation may simultaneously resolve all challenges above. Platelet membrane-coating provides both long circulation and active targeting, leading to preferential internalization by tumor over fibroblast cells in vitro and higher tumor uptake than the red blood cell (RBC) membrane-coated counterpart. Preloading a photodynamic sensitizer into a synthetic nanocarrier shifts its absorption peak to longer wavelength, which favors deep tissue penetration. Upon irradiation with NIR light from a solar simulator at extremely low output power density, the platelet membrane-coated photodynamic-nanoparticle outperforms its RBC membrane-coated counterpart and effectively ablates tumor without causing skin damages, which underscores the importance of active targeting in tumor PDT. We anticipate that platelet membrane coating may facilitate the in vivo applications of antitumor photodynamic therapy. (C) 2018 Elsevier Ltd. All rights reserved.
机译：肿瘤光动力治疗（PDT）的治疗效果受到以下三个挑战的阻碍。反应性氧物质（ROS，PDT的细胞毒因子）极短的寿命将其作用的半径限制为纳米尺度的作用。用活性靶向部分官能化光动力纳米系统有助于将靶细胞带入ROS的范围，但需要额外的研究努力。电流光动力系统一般在近红外（NIR）区域的短端上的光线兴奋;深层组织渗透需要越来越长的NIR光线的发展。减少辐照剂量对于避免皮肤损害但影响治疗结果是必要的;如何解决这一示例仍然是一个挑战。在此表明，在光动力纳米粒子上耦合的血小板膜涂覆与太阳照射可以同时解决上述所有挑战。血小板膜 - 涂层提供长循环和活性靶向，导致肿瘤在体外成纤维细胞和更高的肿瘤摄取的优先内化，而不是红色血细胞（RBC）膜涂覆的对应物。将光动力学敏感剂预加载到合成纳米载体中将其吸收峰变为更长的波长，这使得深层组织渗透。在以极低的输出功率密度从太阳能模拟器辐射来自太阳能模拟器的NIR光时，血小板膜涂覆的光动力学 - 纳米粒子优于其RBC膜涂覆的对应物，并有效地烧蚀肿瘤而不会引起皮肤损伤，这强调了在肿瘤PDT中活性靶向的重要性。我们预期血小板膜涂层可以促进抗肿瘤光动力治疗的体内应用。 （c）2018年elestvier有限公司保留所有权利。

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