Modulation of the NOD-like receptors NOD1 and NOD2: A chemist's perspective

DAmbrosio Elizabeth A.; Drake Walter R.; Mashayekhd Siavash; Ukaegbu Ophelia I; Brown Ashley R.; Grimes Catherine L.

首页> 外文期刊>Bioorganic and Medicinal Chemistry Letters >Modulation of the NOD-like receptors NOD1 and NOD2: A chemist's perspective

【24h】

Modulation of the NOD-like receptors NOD1 and NOD2: A chemist's perspective

机译：NOD1和NOD2的NODα样受体的调节：化学家的观点

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The innate immune system is the body's first defense against invading microorganisms, relying on the recognition of bacterial-derived small molecules by host protein receptors. This recognition event and downstream immune response rely heavily on the specific chemical features of both the innate immune receptors and their bacterial derived ligands. This review presents a chemist's perspective on some of the most crucial and complex components of two receptors (NOD1 and NOD2): starting from the structural and chemical characteristics of bacterial-derived small molecules, to the specific proposed models of molecular recognition of these molecules by immune receptors, to the subsequent post-translational modifications that ultimately dictate downstream immune signaling. Recent advances in the field are discussed, as well as the potential for the development of targeted therapeutics.

机译：天生的免疫系统是对侵袭微生物的尸体的第一种防御，依赖于通过宿主蛋白受体识别细菌衍生的小分子。这种识别事件和下游免疫应答严重依赖于先天免疫受体及其细菌衍生配体的特定化学特征。本综述提出了一种化学家对两种受体中最关键和最复杂的组成部分（NOD1和NOD2）的观点：从细菌衍生的小分子的结构和化学特征开始，到特定的提出的这些分子的分子识别模型免疫受体，到后续翻译后修饰最终决定了下游免疫信号传导。讨论了该领域的最新进展，以及有针对性治疗的潜力。

著录项

来源
《Bioorganic and Medicinal Chemistry Letters》 |2019年第10期|共9页
作者
DAmbrosio Elizabeth A.; Drake Walter R.; Mashayekhd Siavash; Ukaegbu Ophelia I; Brown Ashley R.; Grimes Catherine L.;
展开▼
作者单位

Univ Delaware Dept Chem &

Biochem Newark DE 19716 USA;

Univ Delaware Dept Chem &

Biochem Newark DE 19716 USA;

Univ Delaware Dept Chem &

Biochem Newark DE 19716 USA;

Univ Delaware Dept Chem &

Biochem Newark DE 19716 USA;

Univ Delaware Dept Chem &

Biochem Newark DE 19716 USA;

Univ Delaware Dept Chem &

Biochem Newark DE 19716 USA;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Innate immune receptors; Leucine rich repeat; Peptidoglycan; Nod-like-receptors (NLRs); Modulation of innate immune signaling; Post-translational modification (PTM); Muramyl dipeptides;

机译：天生的免疫受体;亮氨酸重复;肽聚糖;点状受体（NLRS）;调制先天免疫信号传导;翻译后修饰（PTM）;蛋白质二肽;

相似文献

外文文献
中文文献
专利

1. Modulation of the NOD-like receptors NOD1 and NOD2: A chemist's perspective [J] . DAmbrosio Elizabeth A., Drake Walter R., Mashayekhd Siavash, Bioorganic and Medicinal Chemistry Letters . 2019,第10期

机译：NOD1和NOD2的NODα样受体的调节：化学家的观点
2. NOD-like receptors and RIG-I-like receptors in human eosinophils: activation by NOD1 and NOD2 agonists. [J] . Kvarnhammar AM, Petterson T, Cardell LO Immunology: An Official Journal of the British Society for Immunology . 2011,第3期

机译：人嗜酸性粒细胞中的NOD样受体和RIG-I样受体：由NOD1和NOD2激动剂激活。
3. Effects of NOD-like receptors in human B lymphocytes and crosstalk between NOD1/NOD2 and Toll-like receptors [J] . Terese Petterson, Johan Jendholm, Anne M?￥nsson, Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society . 2011,第2期

机译：人B淋巴细胞中NOD样受体的作用以及NOD1 / NOD2与Toll样受体之间的串扰
4. Upregulation of PGRPs by chemically synthesized pathogen-associated molecular patterns via Toll-like receptors, NODI and NOD2 in oral epithelial cells [C] . Akiko Uehara, Yumiko Sugawara, Shoichiro Kurat International Symposium for Interface Oral Health Science . 2005

机译：通过在口腔上皮细胞中通过沟状受体，NODI和NOD2通过化学合成的病原体相关分子模式上调PGRP
5. Molecular basis of NOD1 and NOD2 signaling. [D] . Ver Heul, Aaron Martin. 2013

机译：NOD1和NOD2信号传导的分子基础。
6. NOD-like receptors and RIG-I-like receptors in human eosinophils: activation by NOD1 and NOD2 agonists [O] . Anne Månsson Kvarnhammar, Terese Petterson, Lars-Olaf Cardell 2011

机译：人类嗜酸性粒细胞中的NOD样受体和RIG-I样受体：由NOD1和NOD2激动剂激活
7. Modulation of TLR2, TLR4, TLR5, NOD1 and NOD2 receptor gene expressions and their downstream signaling molecules following thermal stress in the Indian major carp catla () [O] . 2015

机译：印度大鲤鱼卡塔尔热胁迫后TLR2，TLR4，TLR5，NOD1和NOD2受体基因表达及其下游信号分子的调控（）

Modulation of the NOD-like receptors NOD1 and NOD2: A chemist's perspective

摘要

著录项

相似文献

相关主题

期刊订阅