Natural NO inhibitors from the leaves of Callicarpa kwangtungensis: Structures, activities, and interactions with iNOS

Li Shen; Sun Xiaocong; Li Yang; Liu Feng; Ma Jun; Tong Ling; Su Guochen; Xu Jing; Ohizumi Yasushi; Lee Dongho; Guo Yuanqiang

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Natural NO inhibitors from the leaves of Callicarpa kwangtungensis: Structures, activities, and interactions with iNOS

机译：来自Callicarpa Kwangtungensis的叶子的自然无抑制剂：结构，活动和与INOS的相互作用

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A phytochemical investigation to obtain new NO inhibitors resulted in the isolation of a new diterpenoid with a rare 9,10-seco-abietane skeleton (1) and twelve known terpenoids (2-13) from Callicarpa kwangtungensis. Their structures were elucidated on the basis of extensive 1D and 2D NMR spectroscopic data analyses, and the absolute configuration of compound 1 was established by comparison of the calculated and experimental electronic circular dichroism (ECD) spectra. The inhibitory activities on lipopolysaccharide-induced NO production in murine microglial BV-2 cells of these terpenoids were evaluated, and all of the compounds showed inhibitory effects. The following molecular docking studies showed interactions of the bioactive compounds with the iNOS protein. (C) 2016 Elsevier Ltd. All rights reserved.

机译：植物化学研究以获得新的NO抑制剂导致从罕见的9,10-秒 - 上一骨骨架（1）和来自Callicarpa kwangtungensis的罕见的9,10-秒骨架骨架（1）和12-13）分离新的二萜类化合物。它们的结构在广泛的1D和2D NMR光谱数据分析的基础上阐明，并且通过比较计算和实验电子圆形二色性（ECD）光谱来建立化合物1的绝对构型。评价脂多糖诱导的尿素微胶质BV-2细胞的抑制活性在这些萜类化合物的这些萜类化合物中进行了评价，并且所有化合物显示出抑制作用。以下分子对接研究显示了生物活性化合物与InOS蛋白的相互作用。（c）2016 Elsevier Ltd.保留所有权利。

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来源
《Bioorganic and Medicinal Chemistry Letters》 |2017年第3期|共5页
作者
Li Shen; Sun Xiaocong; Li Yang; Liu Feng; Ma Jun; Tong Ling; Su Guochen; Xu Jing; Ohizumi Yasushi; Lee Dongho; Guo Yuanqiang;
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作者单位

Nankai Univ Coll Pharm State Key Lab Med Chem Biol Tianjin 300350 Peoples R China;

Nankai Univ Coll Pharm State Key Lab Med Chem Biol Tianjin 300350 Peoples R China;

Nankai Univ Coll Pharm State Key Lab Med Chem Biol Tianjin 300350 Peoples R China;

Nankai Univ Coll Pharm State Key Lab Med Chem Biol Tianjin 300350 Peoples R China;

Nankai Univ Coll Pharm State Key Lab Med Chem Biol Tianjin 300350 Peoples R China;

Tasly Acad Pharmaceut Anal Inst State Key Lab Core Technol Innovat Chinese Med Tianjin 300410;

Nankai Univ Coll Pharm State Key Lab Med Chem Biol Tianjin 300350 Peoples R China;

Univ Shizuoka Sch Pharmaceut Sci Dept Med Biochem Shizuoka Japan;

Korea Univ Coll Life Sci &

Biotechnol Dept Biosyst &

Biotechnol Seoul 02841 South Korea;

Nankai Univ Coll Pharm State Key Lab Med Chem Biol Tianjin 300350 Peoples R China;

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正文语种 eng
中图分类药学;
关键词
Callicarpa kwangtungensis; 9; 10-seco-Abietane diterpenoid; NO inhibitory activities; iNOS; Molecular docking; Terpenoids;

机译：Callicarpa kwangtungensis;9;10- seco-peietane diterpenoid;没有抑制活动;Inos;分子对接;萜类化合物;

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专利

1. Natural NO inhibitors from the leaves of Callicarpa kwangtungensis: Structures, activities, and interactions with iNOS [J] . Li Shen, Sun Xiaocong, Li Yang, Bioorganic and Medicinal Chemistry Letters . 2017,第3期

机译：来自Callicarpa Kwangtungensis的叶子的自然无抑制剂：结构，活动和与INOS的相互作用
2. Antidiabetic principles of natural medicines. II. Aldose reductase and alpha-glucosidase inhibitors from Brazilian natural medicine, the leaves of Myrcia multiflora DC. (Myrtaceae): structures of myrciacitrins I and II and myrciaphenones A and B. [J] . Yoshikawa M, Shimada H, Nishida N, Chemical and Pharmaceutical Bulletin . 1998,第1期

机译：天然药物的抗糖尿病原则。二。来自巴西天然药物Myrcia multiflora DC的叶子的醛糖还原酶和α-葡萄糖苷酶抑制剂。（桃金娘科）：桃金娘霉素I和II以及桃金娘酮A和B的结构。
3. Antidiabetic principles of natural medicines. II. Aldose reductase and alpha-glucosidase inhibitors from Brazilian natural medicine, the leaves of Myrcia multiflora DC. (Myrtaceae): structures of myrciacitrins I and II and myrciaphenones A and B. [J] . Yoshikawa M, Shimada H, Nishida N, Chemical and Pharmaceutical Bulletin . 1998,第1期

机译：天然药物的抗糖尿病原则。二。来自巴西天然药物Myrcia multiflora DC的叶子的醛糖还原酶和α-葡萄糖苷酶抑制剂。（桃金娘科）：桃金娘霉素I和II以及桃金娘酮A和B的结构。
4. Molecular-electronic mechanism of the toxicity of dioxin and ability of some natural structures to concurrently interact to inhibit its activity [C] . Nguyen Van Tri, Pham The Vung, Dinh Pham Tai, Asia Pacific Electron Paramagnetic Resonance/Electron Spin Resonance Symposium . 2002

机译：分子 - 电子机制的二恶英毒性和一些天然结构的能力同时相互作用，以抑制其活性
5. Part I. Isolation of natural product inhibitors and synthesis of inhibitors of signal transduction. Part II. Structure-activity relationship for a series of glycosidase inhibitors. [D] . Fraser, Rebecca Dawn. 1993

机译：第一部分：天然产物抑制剂的分离和信号转导抑制剂的合成。第二部分一系列糖苷酶抑制剂的构效关系。
6. Isolation Identification and Activities of Natural Antioxidants from Callicarpa kwangtungensis Chun [O] . Hao Cai, Zhiyong Xie, Guanghui Liu, -1

机译：广西Callicarpa Chun天然抗氧化剂的分离鉴定和活性
7. Isolation, identification and activities of natural antioxidants from Callicarpa kwangtungensis Chun. [O] . Hao Cai, Zhiyong Xie, Guanghui Liu, 2014

机译：广东紫珠（Callicarpa kwangtungensis Chun）天然抗氧化剂的分离鉴定及活性

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Natural NO inhibitors from the leaves of Callicarpa kwangtungensis: Structures, activities, and interactions with iNOS

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