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首页> 外文期刊>Bioorganic and Medicinal Chemistry Letters >Sesquiterpene derivatives from marine sponge Smenospongia cerebriformis and their anti-inflammatory activity
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Sesquiterpene derivatives from marine sponge Smenospongia cerebriformis and their anti-inflammatory activity

机译：来自海绵Smenospongia脑脑脑脑脑脑脑脑脑培养的衍生物及其抗炎活动

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摘要

Using various chromatographic methods, five new sesquiterpene derivatives named smenohaimiens A-E (1-5) and five known, 19-hydroxy-polyfibrospongol B (6), ilimaquinone (7), dictyoceratin C (8), polyfibrospongol A (9), and polyfibrospongol B (10) were isolated from the marine sponge Smenospongia cerebriformis Duchassaing & Michelotti, 1864. Their structures were assigned by 1D, 2D NMR spectroscopic analysis, HR ESI MS, and calculations of the electron circular dichroism spectra. All compounds were evaluated for the inhibitory activity against NO production in lipopolysaccharide-stimulated in BV2 microglia cells. As the results, compound 7 significantly inhibited NO production with the IC50 value of 10.40 +/- 1.28 mu M. The remaining compounds showed moderate inhibitory NO production activities with IC50 values ranging from 24.37 to 30.43 mu M. (C) 2017 Elsevier Ltd. All rights reserved.
机译：使用各种色谱法，5名唾弃Smenohaimiens AE（1-5）和5名已知的19-羟基 - 多纤维状醇B（6），Ilimaquinone（7），DictimeratiN C（8），Polyfibrospongol A（9）和Polyfibrospongol B（10）与海绵Smenospongia Cerebriformis Duchassaing和Michelotti，1864年分离。它们的结构由1D，2D NMR光谱分析，HR ESI MS和电子圆形二色性谱的计算分配。 评价所有化合物在BV2微胶质细胞中没有脂多糖刺激的抑制活性。 结果，化合物7显着抑制了IC50值10.40 +/- 1.28 mu M的生产。剩余的化合物显示出中度抑制作用，IC50值范围为24.37至30.43亩M.（c）2017 Elsevier Ltd. 版权所有。

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