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首页> 外文期刊>Biochemical and Biophysical Research Communications >Structural insight into the role of VAL1 B3 domain for targeting to FLC locus in Arabidopsis thaliana
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Structural insight into the role of VAL1 B3 domain for targeting to FLC locus in Arabidopsis thaliana

机译：结构洞察Val1 B3结构域对拟南芥FLC基因座的作用

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摘要

Vernalization is a pivotal stage for some plants involving many epigenetic changes during cold exposure. In Arabidopsis, an essential step in vernalization for further flowering is successful silence the potent floral repressor Flowering Locus C (FLC) by repressing histone mark. AtVal1 is a multi-function protein containing five domains that participate into many recognition processes and is validated to recruit the repress histone modifier PHD-PRC2 complex and interact with components of the ASAP complex target to the FLC nucleation region through recognizing a cis element known as CME (cold memory element) by its plant-specific B3 domain. Here, we determine the crystal structure of the B3 domain in complex with Sph/RY motif in CME. Our structural analysis reveals the specific DNA recognition by B3 domain, combined with our in vitro experiments, we provide the structural insight into the important implication of AtVAL1-B3 domain in flowering process. (C) 2018 Elsevier Inc. All rights reserved.
机译：春化是一种涉及冷暴露过程中许多表观遗传变化的植物的关键阶段。在拟南芥中，通过压制组蛋白标记，进一步开花的春化的重要步骤是进一步开花的进一步开花的重要性沉默。 Atval1是一种多功能蛋白，其包含五个域，其参与许多识别过程，并经过验证以募集抑制组蛋白改性剂PHD-PRC2复合物，并通过识别称为CIS元素与FLC成核区域的ASAP复合物目标的组分相互作用。 CME（冷记忆元件）由其植物特异性B3结构域。这里，我们在CME中确定与SPH / RY基序的复合物中B3结构域的晶体结构。我们的结构分析揭示了B3结构域的特定DNA识别，与我们的体外实验相结合，我们提供了对开花过程中Atval1-B3结构域的重要意义的结构洞察力。 （c）2018年Elsevier Inc.保留所有权利。

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  • 作者

    Wu Baixing; Zhang Mengmeng; Su Shichen; Liu Hehua; Gan Jianhua; Ma Jinbiao;

  • 作者单位

    Fudan Univ Sch Life Sci Inst Plant Biol Dept Biochem State Key Lab Genet Engn Collaborat Innovat;

    Fudan Univ Sch Life Sci Inst Plant Biol Dept Biochem State Key Lab Genet Engn Collaborat Innovat;

    Fudan Univ Sch Life Sci Inst Plant Biol Dept Biochem State Key Lab Genet Engn Collaborat Innovat;

    Fudan Univ Collaborat Innovat Ctr Genet &

    Dev Sch Life Sci Dept Physiol &

    Biophys State Key Lab;

    Fudan Univ Collaborat Innovat Ctr Genet &

    Dev Sch Life Sci Dept Physiol &

    Biophys State Key Lab;

    Fudan Univ Sch Life Sci Inst Plant Biol Dept Biochem State Key Lab Genet Engn Collaborat Innovat;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物化学;
  • 关键词

    Vernalization; Flowering; FLC locus; PRC2; B3 domain; DNA binding;

    机译：vernalization;开花;FLC基因座;PRC2;B3结构域;DNA结合;

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