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首页> 外文期刊>Biochemical and Biophysical Research Communications >Drosophila tensin plays an essential role in cell migration and planar polarity formation during oogenesis by mediating integrin-dependent extracellular signals to actin organization
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Drosophila tensin plays an essential role in cell migration and planar polarity formation during oogenesis by mediating integrin-dependent extracellular signals to actin organization

机译：果蝇在肌动蛋白组织中介导整联蛋白依赖性细胞外信号，在肌菌期间对细胞迁移和平面极性形成起到基本作用

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Oogenesis in Drosophila involves very dynamic cellular changes such as cell migration and polarity formation inside an ovary during short period. Previous studies identified a number of membrane-bound receptors directly receiving certain types of extracellular inputs as well as intracellular signalings to be involved in the regulation of these dynamic cellular changes. However, yet our understanding on exactly how these receptor-mediated extracellular inputs lead to dynamic cellular changes remains largely unclear. Here, we identified Drosophila tensin encoded by blistery (by) as a novel regulator of cell migration and planar polarity formation and characterized the genetic interaction between tensin and integrin during oogenesis. Eggs from by mutant showed decreased hatching rate and morphological abnormality, a round-shape, compared to the wild-type eggs. Further analyses revealed that obvious cellular defects such as defective border cell migration and planar polarity formation might be primarily associated with the decreased hatching rate and the round-shape phenotype of by mutant eggs, respectively. Moreover, by mutation also induced marked defects in F-actin organization closely associated with both cell migration and planar polarity formation during oogenesis of Drosophila. Notably, all these defective phenotypes observed in by mutant eggs became much severer by reduced level of integrin, indicative of a close functional association between integrin and tensin during oogenesis. Collectively, our findings suggest that tensin acts as a crucial regulator of dynamic cellular changes during oogenesis by bridging integrin-dependent extracellular signals to intracellular cytoskeletal organization. (C) 2017 Elsevier Inc. All rights reserved.
机译：果蝇在果蝇中的ofoferesis涉及在短时间内卵巢内部的细胞迁移和极性形成等非常动态的细胞变化。先前的研究确定了许多膜结合受体，直接接受某些类型的细胞外输入以及细胞内信号，以参与这些动态细胞变化的调节。然而，我们对这些受体介导的细胞外输入如何导致动态细胞变化的理解仍然很目前尚不清楚。在此，我们鉴定了由Blistery（by）编码的果蝇苔藓素（逐）作为细胞迁移和平面极性形成的新型调节器，并在ofocaisesis期间表征了芜素和整联素之间的遗传相互作用。与野生型鸡蛋相比，来自突变体的蛋来自突变体的孵化率和形态异常，圆形。进一步的分析表明，诸如边界细胞迁移和平面极性形成的明显细胞缺陷可能主要与突变蛋的降低的阴影率和圆形表型相关联。此外，通过突变还诱导与细胞迁移和平面极性形成密切相关的F-actin组织的显着缺陷在果蝇的果蝇的ofocisesis期间。值得注意的是，通过突变蛋白蛋白观察到的所有这些缺陷表型通过降低的整联蛋白水平变得严重，这表明在ofoferesis期间整联蛋白和张素之间的密切功能关系。我们的研究结果表明，Tensin通过将整合蛋白依赖性细胞外信号桥接到细胞内细胞骨骼组织，作为ofoferis期间的动态细胞变化的关键调节剂。 （c）2017年Elsevier Inc.保留所有权利。

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