首页> 外文期刊>Biosensors & Bioelectronics: The International Journal for the Professional Involved with Research, Technology and Applications of Biosensers and Related Devices >A wearable electrochemical glucose sensor based on simple and low-cost fabrication supported micro-patterned reduced graphene oxide nanocomposite electrode on flexible substrate
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A wearable electrochemical glucose sensor based on simple and low-cost fabrication supported micro-patterned reduced graphene oxide nanocomposite electrode on flexible substrate

机译:基于简单和低成本制造的可穿戴电化学葡萄糖传感器在柔性基板上支撑微图案化的石墨烯氧化物纳米复合电极

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摘要

In this study, a reduced graphene oxide (rGO)-based nanostructured composite working electrode of high quality was successfully microfabricated and micro-patterned on a flexible polyimide substrate using simple low-cost fabrication processes. Gold and platinum alloy nanoparticles were electrochemically deposited onto the microfabricated rGO surface and chitosan-glucose oxidase composites were integrated onto the modified surface of the working electrode to develop a human sweat-based wearable glucose sensor application. The fabricated biosensor exhibited excellent amperometric response to glucose at a detection range of 0-2.4 mM (covers the glucose range in sweat), with a sensitivity of 48 mu A/mMcm(2), a short response time (20 s), and high linearity (0.99). The detection limit for glucose was calculated as 5 mu m. The human sweat/mixing glucose samples initially used for testing indicated acceptable detection performance and stability for low glucose concentrations. These results confirm that the proposed nanostructured composite flexible working electrode and fabrication process are highly promising for application as human sweat-based electrochemical glucose sensors.
机译:在该研究中,使用简单的低成本制造工艺在柔性聚酰亚胺基板上成功地微制成和微观图案化的纳米氧化物(RGO)基础的纳米结构复合工作电极。将金和铂合金纳米颗粒电化学沉积在微制造的RGO表面上,并将壳聚糖 - 葡萄糖氧化酶复合材料集成到工作电极的改性表面上,以开发一种基于人的耐磨葡萄糖传感器应用。制造的生物传感器在0-2.4mm的检测范围内表现出对葡萄糖的优异的葡萄糖响应(覆盖汗液中的葡萄糖范围),灵敏度为48μm/ mmcm(2),短响应时间(20秒)和高线性度(0.99)。葡萄糖的检测限计算为5μm。最初用于测试的人类汗/混合葡萄糖样品表明低葡萄糖浓度的可接受的检测性能和稳定性。这些结果证实,所提出的纳米结构复合柔性工作电极和制造工艺对应用作为人类汗基的电化学葡萄糖传感器具有高度前途。

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