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首页> 外文期刊>BioMed research international >Secondary Focal Segmental Glomerulosclerosis: From Podocyte Injury to Glomerulosclerosis
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Secondary Focal Segmental Glomerulosclerosis: From Podocyte Injury to Glomerulosclerosis

机译:二次焦点细分肾细胞粥样硬化:从肾小球粥样硬化的泛骨赘损伤

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摘要

Focal segmental glomerulosclerosis (FSGS) is a common cause of proteinuria and nephrotic syndrome leading to end stage renal disease (ESRD). There are two types of FSGS, primary (idiopathic) and secondary forms. Secondary FSGS shows less severe clinical features compared to those of the primary one. However, secondary FSGS has an important clinical significance because a variety of renal diseases progress to ESRD thorough the form of secondary FSGS. The defining feature of FSGS is proteinuria. The key event of FSGS is podocyte injury which is caused by multiple factors. Unanswered questions about how these factors act on podocytes to cause secondary FSGS are various and ill-defined. In this review, we provide brief overview and new insights into FSGS, podocyte injury, and their potential linkage suggesting dues to answer for treatment of the disease.
机译:局灶性节段性肾小球粥样硬化(FSGS)是蛋白尿和肾病综合征导致结束阶段肾病(ESRD)的常见原因。 有两种类型的FSGS,初级(特发性)和次要形式。 与主要的FSG相比,次级FSGs显示出不太严重的临床特征。 然而,继发性FSG具有重要的临床意义,因为各种肾病彻底进展到ESRD次要FSG的形式。 FSG的定义特征是蛋白尿。 FSGS的关键事件是具有多种因素引起的泛细胞损伤。 关于这些因素如何对统治性联合细胞引起次要FSG的问题是不同的,并且是不同的。 在本综述中,我们提供简要概述和新的见解,进入FSGS,Podocyte损伤及其潜在的联系,表明会费以应对疾病的治疗。

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