• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Behavioural Brain Research: An International Journal >Fluoxetine normalizes the effects of prenatal maternal stress on depression- and anxiety-like behaviors in mouse dams and male offspring
【24h】

Fluoxetine normalizes the effects of prenatal maternal stress on depression- and anxiety-like behaviors in mouse dams and male offspring

机译：Flyoxetine将产前母体压力对小鼠和雄性后代的抑郁和焦虑行为的影响标准化

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Maternal depression during pregnancy and the postpartum period (lactation) is a common debilitating condition affecting mother-fetus/-infant interactions, which can be a risk factor for cognitive and affective disorders in mothers and their children. Selective-serotonin-reuptake-inhibitor-(SSRI) pharmacotherapy is known as the first-line treatment of maternal depression. However, its use during pregnancy and lactation is a topic of concern. The present study aimed to investigate the effects of prenatal stress alone or in combination with fluoxetine (FLX) on hypothalamic pituitary adrenal axis (HPA) activity, anxiety-/depression-like behaviors in dams and in offspring. To do this, gestationally-stressed and non-stressed mouse dams were orally treated with FLX-(8/mg/kg/day) from gestational day 10 to lactation day 20. The behavioral outcomes of prenatal stress and FLX treatment in dams and male offspring were assessed using the sucrose preference, forced swim, zero maze, and light-dark box tests. Stress-induced corticosterone levels were also evaluated as indicative of abnormal HPA-axis function. Our findings indicated that maternal stress resulted in increased depression-like behavior and HPA axis hyperactivity in dams during pregnancy and lactation which were reversed by FLX. Furthermore, prenatal stress increased anxiety/depression-like behaviors and HPA-axis reactivity in male offspring. These effects were reversed by maternal FLX treatment. Developmental FLX exposure, without prenatal stress, did not have any adverse effects on the above measured parameters. Our results suggest that prenatal stress induces maternal depression-like behavior which affects the development of affective symptoms in male offspring, and that remediation of maternal depression-like behavior coincidences with the normalization of anxiety- and depression-like symptoms in male offspring. (C) 2016 Elsevier B.V. All rights reserved.
机译：妊娠期间的母体抑郁和产后时期（哺乳期）是影响母亲 - 胎儿/ - 粉末相互作用的常见衰弱条件，这可能是母亲和孩子中的认知和情感障碍的危险因素。选择性 - 血清素 - 再摄取抑制剂 - （SSRI）药物治疗被称为母体抑郁的一线治疗。然而，怀孕和哺乳期间的使用是一个关注的主题。本研究旨在探讨产前压力单独或与氟西汀（FLX）组合在下丘脑垂体肾上腺轴（HPA）活性，坝体和后代的焦虑/抑郁状行为组合。为了做到这一点，从妊娠第10天对妊娠第10天口头对抗妊娠和非压力小鼠水坝对哺乳日期20。水坝和男性产前应激和FLX治疗的行为结果使用蔗糖偏好，强制游泳，零迷宫和光暗盒测试评估后代。还评估应激引起的皮质酮水平，如HPA轴功能异常。我们的研究结果表明，孕产妇胁迫导致妊娠和乳液中的抑郁症样行为和HPA轴多动，由FLX逆转。此外，产前压力增加焦虑/抑郁样行为和雄性后代的HPA轴反应性。这些效果被母体FLX治疗逆转。没有产前应激的发育FLX暴露对上述参数没有任何不利影响。我们的研究结果表明，产前应激诱导母体抑郁的行为，这些行为影响雄性后代的情感症状的发展，以及母体抑郁样行为的修复与雄性后代焦虑和抑郁样症状的正常化相吻合。 （c）2016年Elsevier B.v.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号