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首页> 外文期刊>Neuropharmacology >Maternal postpartum corticosterone and fluoxetine differentially affect adult male and female offspring on anxiety-like behavior, stress reactivity, and hippocampal neurogenesis
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Maternal postpartum corticosterone and fluoxetine differentially affect adult male and female offspring on anxiety-like behavior, stress reactivity, and hippocampal neurogenesis

机译：产妇产后皮质酮和氟西汀对成年男性和女性后代的焦虑样行为，应激反应和海马神经发生有不同影响

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摘要

Postpartum depression (PPD) affects approximately 15% of mothers, disrupts maternal care, and can represent a form of early life adversity for the developing offspring. Intriguingly, male and female offspring are differentially vulnerable to the effects of PPD. Antidepressants, such as fluoxetine, are commonly prescribed for treating PPD. However, fluoxetine can reach offspring via breast milk, raising serious concerns regarding the long-term consequences of infant exposure to fluoxetine. The goal of this study was to examine the long-term effects of maternal postpartum corticosterone (CORT, a model of postpartum stress/depression) and concurrent maternal postpartum fluoxetine on behavioral, endocrine, and neural measures in adult male and female offspring. Female Sprague Dawley dams were treated daily with either CORT or oil and fluoxetine or saline from postnatal days 2-23, and offspring were weaned and left undisturbed until adulthood. Here we show that maternal postpartum fluoxetine increased anxiety-like behavior and impaired hypothalamic-pituitary-adrenal (HPA) axis negative feedback in adult male, but not female, offspring. Furthermore, maternal postpartum fluoxetine increased the density of immature neurons (doublecortin-expressing) in the hippocampus of adult male offspring but decreased the density of immature neurons in adult female offspring. Maternal postpartum CORT blunted HPA axis negative feedback in males and tended to increase density of immature neurons in males but decreased it in females. These results indicate that maternal postpartum CORT and fluoxetine can have long-lasting effects on anxiety-like behavior, HPA axis negative feedback, and adult hippocampal neurogenesis and that adult male and female offspring are differentially affected by these maternal manipulations. (C) 2015 Elsevier Ltd. All rights reserved.
机译：产后抑郁症（PPD）会影响约15％的母亲，破坏产妇的护理，并可能代表发育中的后代的早期逆境。有趣的是，雄性和雌性后代在不同程度上容易受到PPD的影响。通常处方抗抑郁药（例如氟西汀）来治疗PPD。但是，氟西汀可以通过母乳到达后代，这引起了对婴儿接触氟西汀的长期后果的严重关注。这项研究的目的是检查产妇皮质酮（CORT，一种产后应激/抑郁模型）和同时产妇氟西汀对成年男性和女性后代的行为，内分泌和神经测量的长期影响。从出生后2-23天起，每天对雌性Sprague Dawley水坝进行CORT或油和氟西汀或生理盐水的治疗，对后代断奶，直至成年。在这里，我们显示了成年男性而非女性的产后产妇氟西汀增加了焦虑样行为，并损害了下丘脑-垂体-肾上腺（HPA）轴负反馈。此外，产后产妇氟西汀增加了成年雄性后代海马中未成熟神经元的密度（表达双皮质素），但降低了成年雌性后代中未成熟神经元的密度。产妇产后CORT在男性中使HPA轴负反馈减弱，并倾向于增加男性中未成熟神经元的密度，但在女性中降低。这些结果表明，产妇产后CORT和氟西汀可对焦虑样行为，HPA轴负反馈和成年海马神经发生产生长期影响，并且成年男性和女性后代受到这些母亲操作的不同影响。 （C）2015 Elsevier Ltd.保留所有权利。

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