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首页> 外文期刊>Behavioural Brain Research: An International Journal >The enduring impact of neurulation stage alcohol exposure: A combined behavioral and structural neuroimaging study in adult male and female C57BL/6J mice
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The enduring impact of neurulation stage alcohol exposure: A combined behavioral and structural neuroimaging study in adult male and female C57BL/6J mice

机译：神经阶段酒精暴露的持久影响：成年男性和雌性C57BL / 6J小鼠的组合行为和结构神经影像研究

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Prenatal alcohol exposure (PAE) can cause behavioral and brain alterations over the lifespan. In animal models, these effects can occur following PAE confined to critical developmental periods, equivalent to the third and fourth weeks of human gestation, before pregnancy is usually recognized. The current study focuses on PAE during early neurulation and examines the behavioral and brain structural consequences that appear in adulthood. On gestational day 8 C57BL/6J dams received two alcohol (2.8 g/kg, i.p), or vehicle, administrations, four hours apart. Male and female offspring were reared to adulthood and examined for performance on the elevated plus maze, rotarod, open field, Morris water maze, acoustic startle, social preference (i.e. three-chambered social approach test), and the hot plate. A subset of these mice was later evaluated using magnetic resonance imaging to detect changes in regional brain volumes and shapes. In males, PAE increased exploratory behaviors on the elevated plus maze and in the open field; these changes were associated with increased fractional anisotropy in the anterior commissure. In females, PAE reduced social preference and the startle response, and decreased cerebral cortex and brain stem volumes. Vehicle-treated females had larger pituitaries than did vehicle-treated males, but PAE attenuated this sex difference. In males, pituitary size correlated with open field activity, while in females, pituitary size correlated with social activity. These findings indicate that early neurulation PAE causes sex specific behavioral and brain changes in adulthood. Changes in the pituitary suggest that this structure is especially vulnerable to neurulation stage PAE.
机译：产前酒精暴露（PAE）会导致寿命的行为和脑改变。在动物模型中，这些效果可能在PAE被局限于关键发育期后发生，相当于人类妊娠的第三周和第四周，通常在怀孕之前被认识到。目前的研究侧重于早期神经抑制期间PAE，并检查成年期出现的行为和脑结构后果。在妊娠第8天8 C57BL / 6J水坝接受了两种酒精（2.8g / kg，i.p）或车辆，施行四个小时。男性和女性后代被饲养到成年期，并在高迷宫，旋转托架，开放场，莫里斯水迷宫，声射击，社会偏好（即三腔社交方法测试）和热板上进行了升高的性能。稍后使用磁共振成像评估这些小鼠的子集，以检测区域脑体积和形状的变化。在雄性中，PAE增加了升高的加迷宫和开放领域的探索性行为;这些变化与前连箱中的分数各向异性增加有关。在女性中，PAE减少了社会偏好和惊吓反应，减少了脑皮层和脑干株。车辆处理的女性比车辆处理的男性更大的垂体，但PAE衰减这种性别差异。在雄性中，垂体大小与开放场活动相关，而在女性中，垂体大小与社会活动相关。这些发现表明，早期的神经素PAE导致成年期的性别特异性行为和脑变化。垂体的变化表明这种结构尤其易受神经阶段PAE的影响。

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