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首页> 外文期刊>Brain research >Oleic acid is a potent inducer for lipid droplet accumulation through its esterification to glycerol by diacylglycerol acyltransferase in primary cortical astrocytes
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Oleic acid is a potent inducer for lipid droplet accumulation through its esterification to glycerol by diacylglycerol acyltransferase in primary cortical astrocytes

机译：油酸是通过其在原发性皮质星形胶质细胞中通过二酰基甘油酰基转移酶对甘油的钠液体积聚的有效诱导剂

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摘要

Astrocytes exhibit an important role in neural lipid metabolism for the regulation of energy balance to supply fatty acids (FAs) and ketone bodies to other neural cells. Lipid droplets (LDs) consisting of neutral- and phospholipids increase in the brains of patients with neurodegenerative diseases, such as Alzheimer's disease and multiple sclerosis. However, the role of LDs and its lipid source remains largely unexplored. Here, we found that oleic acid (OA) was a potent inducer of astrocytic LD accumulation among various FAs. Lipidomic analysis using liquid chromatography equipped with tandem mass spectrometry revealed that the cellular triacylglycerol and phospholipid compositions in astrocytes during LD accumulation reflected the condition of extracellular FAs. Furthermore, the inhibition of diacylglycerol acyltransferase blocked OA-induced LD accumulation and caused lipotoxicity-induced cell death in astrocytes. The present study demonstrated that the formation of LDs, caused due to the increased extracellular OA, facilitated survival against lipotoxic condition.
机译：星形胶质细胞在神经脂质代谢中表现出对能量平衡调节的重要作用，以将脂肪酸（FAS）和酮体提供给其他神经细胞。由中性和磷脂组成的脂质液滴（LDS）组成的神经退行性疾病的患者的大脑，例如阿尔茨海默病和多发性硬化症。但是，LDS及其脂质源的作用仍然很大程度上是未开发的。在这里，我们发现油酸（OA）是各种Fas中的星形胶质细胞LD积累的有效诱导剂。利用配备有串联质谱法的液相色谱分析显示，在LD累积期间，在星形胶质细胞中的细胞三酰基甘油和磷脂组合物反映了细胞外Fas的状况。此外，抑制二酰基甘油酰基转移酶阻断的OA诱导的LD积累并导致星形胶质细胞中的脂毒性诱导的细胞死亡。本研究表明，由于细胞外OA增加而导致的LDS形成，促进对脂毒性病症的存活率。

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