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首页> 外文期刊>Brain research >Long-term consequences of URB597 administration during adolescence on cannabinoid CB1 receptor binding in brain areas.
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Long-term consequences of URB597 administration during adolescence on cannabinoid CB1 receptor binding in brain areas.

机译：URB597在青春期治疗脑区大麻素CB1受体结合时的长期后果。

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Despite the alarming increment in the use and abuse of cannabis preparations among young people, little is known about possible long-term consequences of targeting the endocannabinoid system during the critical developmental period of adolescence. Therefore, we aimed to analyze possible long-lasting neurobiological consequences of enhancing endocannabinoid signalling during adolescence, by means of blocking anandamide (AEA) hydrolysis. Adolescent Wistar male rats were administered an inhibitor of AEA hydrolysis, i.e. URB597 (0, 0.1 or 0.5 mg/kg/day from postnatal days 38 to 43). The expression of brain cannabinoid receptor type 1 (CB1R) was then analyzed by [(3)H]CP-55,940 auto-radiographic binding at adulthood. Repeated URB597 administration during adolescence persistently modified CB1R binding in a region-dependent manner. A long-lasting decrease of CB1R binding levels was found in caudate-putamen, nucleus accumbens, ventral tegmental area and hippocampus, while an opposite increment was observed in the locus coeruleus. Present results provide evidence for long-lasting effects of adolescent URB597 administration. Activation of endocannabinoid transmission during the still plastic phase of adolescence may have implications for the maturational end-point of the endocannabinoid system itself, which could lead to permanent alterations in neuronal brain circuits and behavioural responses. Insights into the developmental trajectories of this neuromodulatory system may help us to better understand and prevent outcomes of neonatal and adolescent cannabis exposure.
机译：尽管在青少年中使用和滥用大麻制剂的使用和滥用大麻制剂的令人震惊，但在青春期关键发育期间靶向内胆蛋白系统的可能长期后果几乎不少。因此，我们旨在通过阻断Aandamide（AEA）水解，分析在青春期期间增强内瘤蟾蜍信号传导的可能的长期神经生物学后果。将青少年Wistar雄性大鼠施用AEA水解的抑制剂，即从后期38至43天到第38至43天的URB597（0,0.1或0.5mg / kg /天）。然后通过[（3）H] CP-55,940 Aut-andaftoghthic结合分析脑大麻素受体型1（CB1R）的表达。在青春期持续修饰的CB1R期间重复URB597给药以区域依赖性方式结合。在甲状腺腐核，核心腺，腹侧三核癌和海马中发现CB1R结合水平的长期减少，而在基因座Coeruleus中观察到相反的增量。目前的结果为青少年URB597管理的长期效果提供了证据。在青春期静脉塑料相期间的环纳米植物透射率的激活可能对内突植物系统本身的良性终点有影响，这可能导致神经元脑电路和行为应答的永久性改变。对该神经调节系统的发育轨迹的见解可能有助于我们更好地理解和预防新生儿和青少年大麻暴露的结果。

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