• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>British Journal of Dermatology >Identifying demographic, social and clinical predictors of biologic therapy effectiveness in psoriasis: a multicentre longitudinal cohort study
【24h】

Identifying demographic, social and clinical predictors of biologic therapy effectiveness in psoriasis: a multicentre longitudinal cohort study

机译：鉴定牛皮癣生物治疗效果的人口，社会和临床预测因子：多期纵向队列研究

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Summary Background Biologic therapies have revolutionized the treatment of moderate‐to‐severe psoriasis. However, for reasons largely unknown, many patients do not respond or lose response to these drugs. Objectives To evaluate demographic, social and clinical factors that could be used to predict effectiveness and stratify response to biologic therapies in psoriasis. Methods Using a multicentre, observational, prospective pharmacovigilance study ( BADBIR ), we identified biologic‐naive patients starting biologics with outcome data at 6 ( n = 3079) and 12 ( n = 3110) months. Associations between 31 putative predictors and outcomes were investigated in univariate and multivariable regression analyses. Potential stratifiers of treatment response were investigated with statistical interactions. Results Eight factors associated with reduced odds of achieving ≥ 90% improvement in Psoriasis Area and Severity Index ( PASI 90) at 6 months were identified (described as odds ratio and 95% confidence interval): demographic (female sex, 0·78, 0·66–0·93); social (unemployment, 0·67, 0·45–0·99); unemployment due to ill health (0·62, 0·48–0·82); ex‐ and current smoking (0·81, 0·66–0·99 and 0·79, 0·63–0·99, respectively); clinical factors (high weight, 0·99, 0·99–0·99); psoriasis of the palms and/or soles (0·75, 0·61–0·91); and presence of small plaques only compared with small and large plaques (0·78, 0·62–0·96). White ethnicity (1·48, 1·12–1·97) and higher baseline PASI (1·04, 1·03–1·04) were associated with increased odds of achieving PASI 90. The findings were largely consistent at 12 months. There was little evidence for predictors of differential treatment response. Conclusions Psoriasis phenotype and potentially modifiable factors are associated with poor outcomes with biologics, underscoring the need for lifestyle management. Effect sizes suggest that these factors alone cannot inform treatment selection.
机译：发明内容背景生物疗法彻底改变了中度至严重的牛皮癣的治疗。然而，由于原因在很大程度上未知，许多患者对这些药物的反应并不反应或失去反应。旨在评估可用于预测效果和分层对牛皮癣生物疗法的效果和分层响应的人口统计学，社会和临床因素。方法采用多中心，观测，前瞻性药物检测研究（Badbir），我们鉴定了在6（n = 3079）和12（n = 3110）个月的结果数据中开始生物学 - 幼稚患者。在单变量和多变量的回归分析中调查了31个推定预测因子和结果之间的关联。用统计相互作用研究了治疗反应的潜在层。结果鉴定了八个与达到60个月内的牛皮癣面积和严重程度指数（PASI 90）达到≥90％的几率相关的八种因素（被描述为赔率比和95％的置信区间）：人口统计（女性，0·78,0 ·66-0·93）;社会（失业，0·67,0·45-0·99）;由于健康状况不佳（0·62,0·48-0·82）失业; ex-and turate吸烟（0·81，0·66-0·99和0·79,0·63-0·99）;临床因素（重量重，0·99,0·99-0·99）;棕榈树和/或鞋底的牛皮癣（0·75,0·61-0·91）;只有小斑块的存在与小斑块（0·78,0·62-0·96）相比。白人民族（1·48,12-1·97）和更高的基线PASI（1·04,103-1·04）与实现PASI 90的几率增加有关。该研究结果在很大一致12个月。差异治疗反应的预测因子几乎没有证据。结论牛皮癣表型和潜在可修饰的因素与生物制剂的差，强调了生活方式管理的需求。效果大小表明，仅这些因素无法通知治疗选择。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号