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首页> 外文期刊>British Journal of Dermatology >Core outcome sets in dermatology: report from the second meeting of the International Cochrane Skin Group Core Outcome Set Initiative
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Core outcome sets in dermatology: report from the second meeting of the International Cochrane Skin Group Core Outcome Set Initiative

机译：皮肤科核心结果套：从国际Cochrane皮肤集团核心成果设定倡议的第二次会议报告

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摘要

Summary Results of clinical trials are the most important information source for generating external clinical evidence. The use of different outcomes across trials, which investigate similar interventions for similar patient groups, significantly limits the interpretation, comparability and clinical application of trial results. Core outcome sets (COS s) aim to overcome this limitation. ACOS is an agreed standardized collection of outcomes that should be measured and reported in all clinical trials for a specific clinical condition. The Core Outcome Set Initiative within the Cochrane Skin Group (CSG COUSIN ) supports the development of core outcomes in dermatology.In the secondCSG COUSIN meeting held in 2017, 11COS development groups working on skin diseases presented their current work. The presentations and discussions identified the following overarching methodological challenges forCOS development in dermatology: it is not always easy to define the disease focus of aCOS ; the optimal method for outcome domain identification and level of detail needed to specify such domains is challenging to many; decision rules within Delphi surveys need to be improved; appropriate ways of patient involvement are not always clear. In addition, there appear to be outcome domains that may be relevant as potential core outcome domains for the majority of skin diseases. The close collaboration between methodologists in the Core Outcome Set Initiative and the international Cochrane Skin Group has major advantages for trialists, systematic reviewers andCOS developers.
机译：临床试验的概要结果是产生外部临床证据的最重要信息资源。在试验中使用不同的结果，该试验研究了类似患者群体的类似干预，显着限制了试验结果的解释，可比性和临床应用。核心结果组（COS）旨在克服这一限制。 ACOS是一项商定的标准化成果，应在所有临床试验中测量和报告的特定临床状况。 Cochrane皮肤集团（CSG Cousin）内的核心结果设定倡议支持皮肤科核心结果的发展。在2017年举行的第二次召开表兄弟会议上，11COS开发群体致力于皮肤病患者的工作。陈述和讨论确定了皮肤科的FORCOS发育的总体方法挑战：定义ACOS的疾病焦点并不总是容易;指定此类域所需的结果域识别和详细程度的最佳方法是挑战许多;需要改进Delphi调查中的决策规则;适当的患者参与方式并不总是清晰。此外，似乎存在可能与大多数皮肤病的潜在核心成果域有关。核心成果设定倡议和国际Cochrane皮肤集团在核心成果方案倡议和国际Cochrane皮肤集团之间的密切合作对试验医生来说，系统审稿人和科学开发人员具有重要优势。

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  • 来源
    《British Journal of Dermatology》 |2018年第4期|共7页
  • 作者

    Kottner J.; Jacobi L.; Hahnel E.; Alam M.; Balzer K.; Beeckman D.; Busard C.; Chalmers J.; Deckert S.; Eleftheriadou V.; Furlan K.; Horbach S.E.R.; Kirkham J.; Nast A.; Spuls P.; Thiboutot D.; Thorlacius L.; Weller K.; Williams H.C.; Schmitt J.; International Cochrane Skin Group Core Outcome Set Initiative (CSG‐COUSIN) group;

  • 作者单位

    Department of Dermatology and AllergyCharité‐Universit?tsmedizin BerlinBerlin Germany;

    Center for Evidence‐based HealthcareMedizinische Fakult?t Carl Gustav CarusDresden Germany;

    Department of Dermatology and AllergyCharité‐Universit?tsmedizin BerlinBerlin Germany;

    Department of DermatologyNorthwestern UniversityChicago IL U.S.A.;

    Institute for Social Medicine and EpidemiologyUniversity of LübeckGermany;

    Department of Public HealthUniversity Centre for Nursing and MidwiferyGhent Belgium;

    Department of DermatologyAcademic Medical CenterAmsterdam the Netherlands;

    Centre of Evidence Based DermatologyUniversity of NottinghamNottingham U.K.;

    Center for Evidence‐based HealthcareMedizinische Fakult?t Carl Gustav CarusDresden Germany;

    Centre of Evidence Based DermatologyUniversity of NottinghamNottingham U.K.;

    Department of DermatologyNorthwestern UniversityChicago IL U.S.A.;

    Department of DermatologyAcademic Medical CenterAmsterdam the Netherlands;

    Department of BiostatisticsUniversity of LiverpoolLiverpool U.K.;

    Department of Dermatology and AllergyCharité‐Universit?tsmedizin BerlinBerlin Germany;

    Department of DermatologyAcademic Medical CenterAmsterdam the Netherlands;

    Department of DermatologyThe Pennsylvania State University College of MedicineHershey PA U.S.A.;

    Department of DermatologyZealand University HospitalRoskilde Denmark;

    Department of Dermatology and AllergyCharité‐Universit?tsmedizin BerlinBerlin Germany;

    Centre of Evidence Based DermatologyUniversity of NottinghamNottingham U.K.;

    Center for Evidence‐based HealthcareMedizinische Fakult?t Carl Gustav CarusDresden Germany;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 皮肤病学与性病学;
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