The relevance of performing developmental toxicity studies about ayahuasca.

Oliveira CD; Moreira CQ; Marques de Sa LR; de Souza Spinosa H; Yonamine M

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The relevance of performing developmental toxicity studies about ayahuasca.

机译：开展关于阿hua华的发育毒性研究的相关性。

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Response to the Letter to the Editor Ref: BDRD-10-0049-Toxicity of chronic ayahuasca administration to the pregnant rat: how relevant it is regarding the human, ritual use of ayahuasca? Author: Rafael Guimaraes dos Santos. First of all, we thank the author for his important comments regarding our recently published article entitled "Maternal and developmental toxicity of ayahuasca in Wistar rats." This is a great opportunity to discuss some points that were not detailed in the original text. As the author states in his letter, this is the first study that shows toxic effects of chronic exposure to ayahuasca in pregnant rats and their offspring.

机译：对给编辑的信的答复编号：BDRD-10-0049-长期使用阿育吠陀对怀孕大鼠的毒性：它与人类，常规使用的阿育吠陀有何关联？作者：Rafael Guimaraes dos Santos。首先，我们感谢作者对我们最近发表的题为“阿瓦斯卡对Wistar大鼠的母体和发育毒性”的重要评论。这是一个很好的机会来讨论原始文本中未详述的一些要点。正如作者在信中指出的那样，这是第一项显示长期暴露于怀孕大鼠及其后代的hua树花的毒性作用的研究。

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《Birth defects research, Part B. Developmental and reproductive toxicology》 |2010年第6期|共5页
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Oliveira CD; Moreira CQ; Marques de Sa LR; de Souza Spinosa H; Yonamine M;
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1. The relevance of performing developmental toxicity studies about ayahuasca. [J] . Oliveira CD, Moreira CQ, Marques de Sa LR, Birth defects research, Part B. Developmental and reproductive toxicology . 2010,第6期

机译：开展关于阿hua华的发育毒性研究的相关性。
2. Review of embryo-fetal developmental toxicity studies performed for pharmaceuticals approved by FDA in 2016 and 2017 [J] . Paul Barrow Reproductive toxicology . 2018,第期

机译：审查2016年和2017年FDA批准的药品进行胚胎发育毒性研究
3. Review of embryo-fetal developmental toxicity studies performed for recent FDA-approved pharmaceuticals [J] . Ishihara-Hattori Kana, Barrow Paul Reproductive toxicology . 2016,第Null期

机译：对最近FDA批准的药物进行的胚胎-胎儿发育毒性研究的评论
4. Characterization of bone abnormalities from micro-CT images for evaluating drug toxicity in developmental and reproductive toxicology (DART) studies [C] . Dogdas Belma, Antong Chen, Mehta Saurin, IEEE International Symposium on Biomedical Imaging . 2015

机译：从微型CT图像表征骨骼异常，以评估发育和生殖毒理学（DART）研究中的药物毒性
5. Studies on the Developmental Toxicity of Mixtures of the Water Chlorination By-products Dichloroacetate and Trichloroacetate in Zebrafish Embryos: Association with the Induction of Oxidative Stress [D] . Issa, Omar Nabil. 2019

机译：斑马鱼胚胎中水氯化副产物二氯乙酸和三氯乙酸混合物发育毒性的研究：与氧化胁迫诱导相关性
6. Lack of human relevance for procymidone’s developmental toxicity attributable to species difference in its kinetics and metabolism [O] . Yoshitaka Tomigahara, Hirokazu Tarui, Masayoshi Matsui, 2018

机译：由于脯氨酰胺的动力学和代谢存在物种差异因此缺乏与丙胺酮的发育毒性相关的人类相关性
7. Comments from the Developmental Neurotoxicology Committee of the Japanese Teratology Society on the OECD Guideline for the Testing of Chemicals, Proposal for a New Guideline 426, Developmental Neurotoxicity Study, Draft Document (October 2006 version), and on the Draft Document of the Retrospective Performance Assessment of the Draft Test Guideline 426 on Developmental Neurotoxicity [O] . Makoto Ema, Yoshihiro Fukui, Hiroaki Aoyama, 2007

机译：日本Teratology社会发育性神经毒理学委员会的评论对化学品测试的经合组织，新指南426的提案，发育神经毒性研究，文件草案（2006年10月版），以及回顾性能评估的文件草案作者：张莹莹，王莹，作用
8. Results of an Oral Prenatal Developmental Toxicity Study in Rats, an Oral Reproduction/Developmental Toxicity Screening Test in Rats, a 13-Week Oral Toxicity Study in Rats, an In vivo Mammalian Erythrocyte Micronucleus Test in Mice, an In Vivo Micronucleu [R] . 2011

机译：大鼠口服产前发育毒性研究结果，大鼠口服繁殖/发育毒性筛查试验，大鼠13周口服毒性研究，小鼠体内哺乳动物红细胞微核试验，体内微核

The relevance of performing developmental toxicity studies about ayahuasca.

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