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首页> 外文期刊>Anemia >Hematological Indices for Differential Diagnosis of Beta Thalassemia Trait and Iron Deficiency Anemia
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Hematological Indices for Differential Diagnosis of Beta Thalassemia Trait and Iron Deficiency Anemia

机译：鉴别β地中海贫血性状和缺铁性贫血的血液学指标

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摘要

Background. The two most frequent types of microcytic anemia are beta thalassemia trait (beta-TT) and iron deficiency anemia (IDA). We retrospectively evaluated the reliability of various indices for differential diagnosis of microcytosis and beta-TT in the same patient groups. Methods. A total of 290 carefully selected children aged 1.1-16 years were evaluated. We calculated 12 discrimination indices in all patients with hemoglobin (Hb) values of 8.7-11.4 g/dL. None of the subjects had a combined case of IDA and beta-TT. All children with IDA received oral iron for 16 weeks, and HbA2 screening was performed after iron therapy. The patient groups were evaluated according to red blood cell (RBC) count; red blood distribution width index; the Mentzer, Shine and Lai, England and Fraser, Srivastava and Bevington, Green and King, Ricerca, Sirdah, and Ehsani indices; mean density of hemoglobin/liter of blood; and mean cell density of hemoglobin. Results. The Mentzer index was the most reliable index, as it had the highest sensitivity (98.7%), specificity (82.3%), and Youdens index (81%) for detecting beta-TT; this was followed by the Ehsani index (94.8%, 73.5%, and 68.3%, resp.) and RBC count (94.8%, 70.5%, and 65.3%). Conclusion. The Mentzer index provided the highest reliabilities for differentiating beta-TT from IDA.
机译：背景。小细胞性贫血的两种最常见类型是β地中海贫血特征（β-TT）和铁缺乏性贫血（IDA）。我们回顾性评估了在同一患者组中对微细胞增多症和β-TT进行鉴别诊断的各种指标的可靠性。方法。总共对290名1.1-16岁的精心挑选的儿童进行了评估。我们计算了所有血红蛋白（Hb）值为8.7-11.4 g / dL的患者的歧视指数。没有一个受试者患有IDA和beta-TT的合并病例。所有IDA儿童均接受口服铁剂治疗16周，铁剂治疗后进行HbA2筛查。根据红细胞（RBC）计数评估患者组;红血分布宽度指数; Mentzer，Shine和Lai，英格兰和Fraser，Srivastava和Bevington，Green和King，Ricerca，Sirdah和Ehsani指数;平均血红蛋白密度/升血液;和血红蛋白的平均细胞密度。结果。 Mentzer指数是最可靠的指数，因为它对检测β-TT的灵敏度最高（98.7％），特异性（82.3％）和Youdens指数（81％）;其次是Ehsani指数（分别为94.8％，73.5％和68.3％）和RBC计数（94.8％，70.5％和65.3％）。结论。 Mentzer指数为区分beta-TT和IDA提供了最高的可靠性。

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