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首页> 外文期刊>Chemistry: A European journal >An Unsymmetrical Squaraine-Based Activatable Probe for Imaging Lymphatic Metastasis by Responding to Tumor Hypoxia with MSOT and Aggregation-Enhanced Fluorescent Imaging
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An Unsymmetrical Squaraine-Based Activatable Probe for Imaging Lymphatic Metastasis by Responding to Tumor Hypoxia with MSOT and Aggregation-Enhanced Fluorescent Imaging

机译：基于非对称的Squaraine的可活性探针，用于通过瘤族和聚集增强的荧光成像响应肿瘤缺氧进行成像淋巴转离症

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摘要

Optoacoustic imaging has great potential for preclinical research and clinical practice, and designing robust activatable optoacoustic probes for specific diseases is beneficial for its further development. Herein, an activatable probe has been developed for tumor hypoxia imaging. For this probe, indole and quinoline were linked on each side of an oxocyclobutenolate core to form an unsymmetrical squaraine. A triarylamine group was incorporated to endow the molecule with the aggregation enhanced emission (AEE) properties. In aqueous media, the squaraine chromophore aggregates into the nanoprobe, which specifically responds to nitroreductase and produces strong optoacoustic signals due to its high extinction coefficient, as well as prominent fluorescence emission as a result of its AEE feature. The nanoprobe was used to image tumor metastasis via the lymphatic system both optoacoustically and fluorescently. Moreover, both the fluorescence signals and three-dimensional multispectral optoacoustic tomography signals from the activated nanoprobe allow us to locate the tumor site and to map the metastatic route.
机译：光声成像具有巨大的临床前研究和临床实践的潜力，并且针对特定疾病的鲁棒激活光声探针对其进一步发展有益。在此，已经开发了一种可活化的探针用于肿瘤缺氧成像。对于该探针，吲哚和喹啉在氧冷丁蛋白酸盐核的每一侧连接以形成不对称的鳞片。三芳基胺基掺入以赋予分子与聚集增强的发射（AEE）性质。在水性介质中，Squaraine发色团聚集到NaNoPobe中，该纳米骨瓣特异性地响应硝化酶，并且由于其高消光系数而产生强的光声信号，以及由于其AEE特征而突出的荧光发射。纳泊骨瓣用于通过光声和荧光的淋巴系统进行肿瘤转移。此外，来自活化的纳米孔的荧光信号和三维多光谱断层扫描信号允许我们定位肿瘤部位并映射转移途径。

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  • 来源
    《Chemistry: A European journal》 |2019年第72期|共8页
  • 作者

    Yi Lin; Lihe Sun; Fang Zeng; Shuizhu Wu;

  • 作者单位

    State Key Laboratory of Luminescent Materials and Devices Key Laboratory of Luminescence from Molecular Aggregates of Guangdong Province College of Materials Science and Engineering South China University of Technology Wushan Road 381 Guangzhou 510640;

    State Key Laboratory of Luminescent Materials and Devices Key Laboratory of Luminescence from Molecular Aggregates of Guangdong Province College of Materials Science and Engineering South China University of Technology Wushan Road 381 Guangzhou 510640;

    State Key Laboratory of Luminescent Materials and Devices Key Laboratory of Luminescence from Molecular Aggregates of Guangdong Province College of Materials Science and Engineering South China University of Technology Wushan Road 381 Guangzhou 510640;

    State Key Laboratory of Luminescent Materials and Devices Key Laboratory of Luminescence from Molecular Aggregates of Guangdong Province College of Materials Science and Engineering South China University of Technology Wushan Road 381 Guangzhou 510640;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 应用化学;
  • 关键词

    aggregation-enhanced emission; fluorescent probes; imaging agents; optoacoustic tomography; squaraines;

    机译：聚集增强的发射;荧光探针;成像代理;光声断层扫描;Squaraines;

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