Structure and dynamics of triazole-linked DNA: Biocompatibility explained

Dallmann A.; El-Sagheer A.H.; Dehmel L.; Mügge C.; Griesinger C.; Ernsting N.P.; Brown T.

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Structure and dynamics of triazole-linked DNA: Biocompatibility explained

机译：三唑连接的DNA的结构和动态：生物相容性解释

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Blending in: A triazole-modified DNA duplex is perturbed in structure and dynamics, but this is delocalized over five base pairs. The conformation remains B-DNA and hydrogen bonds between the DNA phosphate oxygen and polymerases can be mimicked by the triazole nitrogen (see figure). The results explain the surprising biocompatibility of triazole-linked DNA.

机译：混合：三唑改性的DNA双工是在结构和动态的扰动中，但这是在五个碱基对上划分的。构象仍然是DNA磷酸盐氧和聚合酶之间的氢键可以被三唑氮模仿（见图）。结果解释了三唑连接DNA的令人惊讶的生物相容性。

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《Chemistry: A European journal》 |2011年第52期|共4页
作者
Dallmann A.; El-Sagheer A.H.; Dehmel L.; Mügge C.; Griesinger C.; Ernsting N.P.; Brown T.;
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作者单位

Department of Chemistry Humboldt-Universit?t zu Berlin 12489 Berlin Germany;

School of Chemistry University of Southampton Highfield Southampton SO17 1BJ United Kingdom;

Department of Chemistry Humboldt-Universit?t zu Berlin 12489 Berlin Germany;

Department of Chemistry Humboldt-Universit?t zu Berlin 12489 Berlin Germany;

Department of NMR-Based Structural Biology Max-Planck Institute for Biophysical Chemistry 37077 G?ttingen Germany;

Department of Chemistry Humboldt-Universit?t zu Berlin 12489 Berlin Germany;

School of Chemistry University of Southampton Highfield Southampton SO17 1BJ United Kingdom;

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原文格式 PDF
正文语种 eng
中图分类应用化学;
关键词
click chemistry; DNA; DNA recognition; NMR spectroscopy; nucleic acids;

机译：点击化学;DNA;DNA识别;NMR光谱;核酸;

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1. Structure and Dynamics of Triazole-Linked DNA: Biocompatibility Explained [J] . Dr. André Dallmann, Dr. Afaf H. El-Sagheer, Dipl.-Chem. Lars Dehmel, Chemistry - A European Journal . 2011,第52期

机译：三唑连接的DNA的结构和动力学：生物相容性解释。
2. Assembly of a biocompatible triazole-linked gene by one-pot click-DNA ligation [J] . Kukwikila Mikiembo, Gale Nittaya, El-Sagheer Afaf H., Nature Chemistry . 2017,第11期

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4. NONLINEAR DYNAMICS OF INTERCONNECTED STRUCTURES - AN APPLICATION TO DNA DYNAMICS [C] . Amit Shukla American Society of Mechanical Engineers(ASME) International Design Engineering Technical Conference and Computers and Information in Engineering Conference(DETC2005) vol.6 pt.C: International Conference on Multibody Systems, Nonlinear Dynamics, and Cont . 2005

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Structure and dynamics of triazole-linked DNA: Biocompatibility explained

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